Tidal airway closure in asthma and COPD

Claudio Tantucci, Laura Pini
  • Claudio Tantucci
    Affiliation not present

Abstract

Functional closure of small airways can occur during tidal breathing above functional residual capacity (FRC) both in asthma and COPD patients, especially during exacerbations. Such event has several noxious consequences on gas exchange, airway hyperresponsiveness and mechanical stress and strain within lung tissue and airway wall, mostly due to increase in ventilation heterogeneity. The availability of simple functional tests based on sequential measurements of lung volumes (i.e.: FRC), by plethysmography and dilutional techniques may reveal and monitor easily tidal airway closure that can be and should be treated with the aim of abolishing or at least reducing this dangerous condition.

Keywords

Tidal airway closure, FRC, plethysmography, dilutional techniques

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Submitted: 2016-11-04 23:07:21
Published: 2016-11-23 15:23:15
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Copyright (c) 2016 Claudio Tantucci, Laura Pini

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