Review of the association between periodontitis and chronic obstructive pulmonary disease in smokers

https://doi.org/10.4081/monaldi.2019.1018

Authors

  • Agathi Spiropoulou Aristotle University of Thessaloniki, School of Dentistry, Greece.
  • Nicholas Zareifopoulos | nizareifopoulos@gmail.com University of Patras School of Medicine, Department of Pulmonology, Greece.
  • Aggeliki Bellou University of Patras School of Medicine, Department of Pulmonology, Greece.
  • Konstantinos Spiropoulos Aristotle University of Thessaloniki, School of Dentistry, Greece.
  • Lazaros Tsalikis Aristotle University of Thessaloniki, School of Dentistry, Greece.

Abstract

Both periodontitis and chronic obstructive pulmonary disease (COPD) are among the most common diseases associated with smoking. These conditions frequently present alongside comorbidities including diabetes, coronary heart disease, duodenal ulcer, deep vein thrombosis, pulmonary embolism, osteoporosis and muscle atrophy. Chronic inflammation contributes to the pathology of both periodontitis and COPD, and in patients suffering from both conditions treatment of periodontitis may lead to relief from COPD symptoms as well. Smoking contributes to the underlying pathophysiology by causing local inflammation, increasing the production of proinflammatory cytokines and most importantly, by locally increasing the activity of proteolytic enzymes which degrade the extracellular matrix in both periodontal and lung interstitial tissue. The increase in protease activity and extracellular matrix degradation may explain why periodontitis and COPD comorbidity is so common, a finding which also indicates that therapeutic interventions targeting protease activity and the inflammatory response may be beneficial for both conditions.

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Published
2019-03-20
Info
Issue
Section
Pneumology - Reviews
Keywords:
Chronic Obstructive Pulmonary Disease, Edentulism, Inflammation, Metalloproteinase, Periodontitis
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  • PDF: 1067
How to Cite
Spiropoulou, Agathi, Nicholas Zareifopoulos, Aggeliki Bellou, Konstantinos Spiropoulos, and Lazaros Tsalikis. 2019. “Review of the Association Between Periodontitis and Chronic Obstructive Pulmonary Disease in Smokers”. Monaldi Archives for Chest Disease 89 (1). https://doi.org/10.4081/monaldi.2019.1018.

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