Probe-based confocal laser endomicroscopy in diagnosis of desquamative interstitial pneumonia in nonsmoker

  • Igor S. Mamenko | dr.mamenko.is@gmail.com St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia; Medical Faculty, St. Petersburg State University, St. Petersburg, Russian Federation.
  • Igor V. Vasilev St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, St. Petersburg, Russian Federation.
  • Irina A. Tabanakova St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, St. Petersburg, Russian Federation.
  • Sultan M. Gasanmagomedov St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Russian Federation.
  • Vera V. Sysoeva St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Russian Federation.
  • Alexey D. Ushkov St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Russian Federation.
  • Tatiana A. Novickaya St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia; Medical Faculty, St. Petersburg State University, St. Petersburg, Russian Federation.
  • Piotr K. Yablonskii St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia; Medical Faculty, St. Petersburg State University, St. Petersburg, Russian Federation.

Abstract

Desquamative interstitial pneumonia is a rare disease that is predominantly associated with smoking. Surgical biopsy is usually recommended for the diagnosis of this disorder. Probe-based confocal laser endomicroscopy (pCLE) is a new method of minimally invasive in vivo microscopic image of airways and alveoli. We use this method for desquamative interstitial pneumonia in nonsmoker. The pCLE image shows thickened intra-alveolar septae and clusters of autofluorescent cells within the alveoli, which is unusual for non-smoking patients. We think this pattern can be used for differential diagnosis of desquamative interstitial pneumonia in nonsmokers.

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Published
2019-09-10
Info
Issue
Section
Pneumology - Case Reports
Keywords:
confocal laser endomicroscopy, optical biopsy, interstitial lung diseases, idiopathic interstitial pneumonias, desquamative interstitial pneumonia
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How to Cite
Mamenko, I. S., Vasilev, I. V., Tabanakova, I. A., Gasanmagomedov, S. M., Sysoeva, V. V., Ushkov, A. D., Novickaya, T. A., & Yablonskii, P. K. (2019). Probe-based confocal laser endomicroscopy in diagnosis of desquamative interstitial pneumonia in nonsmoker. Monaldi Archives for Chest Disease, 89(3). https://doi.org/10.4081/monaldi.2019.1052