Probe-based confocal laser endomicroscopy in diagnosis of desquamative interstitial pneumonia in nonsmoker

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Igor S. Mamenko *
Igor V. Vasilev
Irina A. Tabanakova
Sultan M. Gasanmagomedov
Vera V. Sysoeva
Alexey D. Ushkov
Tatiana A. Novickaya
Piotr K. Yablonskii
(*) Corresponding Author:
Igor S. Mamenko | dr.mamenko.is@gmail.com

Abstract

Desquamative interstitial pneumonia is a rare disease that is predominantly associated with smoking. Surgical biopsy is usually recommended for the diagnosis of this disorder. Probe-based confocal laser endomicroscopy (pCLE) is a new method of minimally invasive in vivo microscopic image of airways and alveoli. We use this method for desquamative interstitial pneumonia in nonsmoker. The pCLE image shows thickened intra-alveolar septae and clusters of autofluorescent cells within the alveoli, which is unusual for non-smoking patients. We think this pattern can be used for differential diagnosis of desquamative interstitial pneumonia in nonsmokers.


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