Case Reports
26 November 2015
Vol. 79 No. 1 (2013): Pulmonary series
https://doi.org/10.4081/monaldi.2013.109

Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review

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Bladder carcinoma, Bacilllus Calmette-Guérin (BCG) immunotherapy, Pneumonia, CAP
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G. Caramori
gaetano.caramori@unife.it
Sezione di Malattie dell’Apparato Respiratorio, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell’Apparato Respiratorio (CEMICEF), Dipartimento di Scienze Mediche, University of Ferrara, Italy.
D. Artioli
Sezione di Malattie dell’Apparato Respiratorio, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell’Apparato Respiratorio (CEMICEF), Dipartimento di Scienze Mediche, University of Ferrara, Italy.
G. Ferrara
Lung Allergi Kliniken, Karolinska University Hospital, Stockholm, Sweden.
R. Cazzuffi
Sezione di Malattie dell’Apparato Respiratorio, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell’Apparato Respiratorio (CEMICEF), Dipartimento di Scienze Mediche, University of Ferrara, Italy.
C. Pasquini
Sezione di Malattie dell’Apparato Respiratorio, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell’Apparato Respiratorio (CEMICEF), Dipartimento di Scienze Mediche, University of Ferrara, Italy.
M. Libanore
Sezione di Malattie Infettive, Dipartimento di Scienze Mediche, University of Ferrara, Italy.
V. Guardigni
Sezione di Malattie Infettive, Dipartimento di Scienze Mediche, University of Ferrara, Italy.
I. Guzzinati
Sezione di Malattie dell’Apparato Respiratorio, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell’Apparato Respiratorio (CEMICEF), Dipartimento di Scienze Mediche, University of Ferrara, Italy.
M. Contoli
Sezione di Malattie dell’Apparato Respiratorio, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell’Apparato Respiratorio (CEMICEF), Dipartimento di Scienze Mediche, University of Ferrara, Italy.
R. Rossi
Microbiology Department, Arcispedale S. Anna, Ferrara, Italy.
R. Rinaldi
Sezione di Anatomia-Patologica, Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, University of Ferrara, Italy.
C. Contini
Sezione di Malattie Infettive, Dipartimento di Scienze Mediche, University of Ferrara, Italy.
A. Papi
Sezione di Malattie dell’Apparato Respiratorio, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell’Apparato Respiratorio (CEMICEF), Dipartimento di Scienze Mediche, University of Ferrara, Italy.
We present here the case of a 66 year old man with a severe bilateral community acquired pneumonia secondary to dissemination after an intravesical instillation of bacilllus Calmette-Guérin (BCG). Diagnosis was based on positive polymerase chain reaction (PCR) for mycobacterium tuberculosis complex in bronchoalveolar lavage and on the finding on transbronchial biopsy of non necrotising granulomas histopathologically similar to the granulomas found in bladder biopsies. These findings were confirmed using a validated real time PCR assay demonstrating the presence of the BCG genome in transbronchial and bladder biopsies.

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“Severe Pneumonia After Intravesical BCG Instillation in a Patient With Invasive Bladder Cancer: Case Report and Literature Review”. 2015. Monaldi Archives for Chest Disease 79 (1). https://doi.org/10.4081/monaldi.2013.109.