Endothelial progenitor cells and vascular health: effects of lifestyle’s modifications

https://doi.org/10.4081/monaldi.2012.125

Authors

  • Francesca Cesari | francesca.cesari@gmail.com Department of Medical and Surgical Critical Care, Thrombosis Centre; University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Anna Maria Gori Department of Medical and Surgical Critical Care, Thrombosis Centre; University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Ilaria Romagnuolo Department of Medical and Surgical Critical Care, Thrombosis Centre; University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Rosanna Abbate Department of Medical and Surgical Critical Care, Thrombosis Centre; University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Abstract

During the last years increasing evidence showed that bone marrow-derived cells with angiogenic capability, named endothelial progenitor cells (EPCs), possess the capacity to home to sites of vascular injury, so contributing to the neoangiogenesis in vivo and to the maintenance of the homeostasis of vascular endothelium. Currently, potent triggers for the mobilisation of EPCs from bone-marrow are known. In addition to some pharmacological treatment such as statins, erythropoietin, PPAR-gamma agonists and angiotensin-II receptor antagonists, the effects of healthy lifestyle, via mobilization and functional improvement of EPC, is increasingly recognized. In this review we analyze, the effects of lifestyle interventions on EPCs. In particular we will focus on physical activity and cardiac rehabilitation protocols, weight reduction, and smoking cessation. Moreover, the negative effects of depression, mood disturbances and type D-personality on EPCs are also considered.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Downloads

Published
2015-12-01
Info
Issue
Section
Reviews
Keywords:
endothelial progenitor cells, endothelial function, lifestyle, prevention.
Statistics
  • Abstract views: 627

  • PDF: 449
How to Cite
Cesari, Francesca, Anna Maria Gori, Ilaria Romagnuolo, and Rosanna Abbate. 2015. “Endothelial Progenitor Cells and Vascular Health: Effects of lifestyle’s Modifications”. Monaldi Archives for Chest Disease 78 (2). https://doi.org/10.4081/monaldi.2012.125.