Cerebrovascular events in COVID-19 patients

  • Ajay Kumar Mishra Department of Internal Medicine, St. Vincent Hospital, Worcester, MA, United States.
  • Kamal Kant Sahu Department of Internal Medicine, St. Vincent Hospital, Worcester, MA, United States. https://orcid.org/0000-0002-0382-6882
  • Anu Anna George Department of Internal Medicine, St. Vincent Hospital, Worcester, MA, United States.
  • Jennifer Sargent Department of Internal Medicine, St. Vincent Hospital, Worcester; University of Massachusetts Medical School, Worcester, MA, United States. https://orcid.org/0000-0003-4323-5523
  • Amos Lal | manavamos@gmail.com Department of Internal Medicine, Division of Pulmonology and Critical Care Medicine, Mayo Clinic, Rochester, MN, United States. https://orcid.org/0000-0002-0021-2033

Abstract

Neurological manifestations in patients with COVID–19 are more frequently being reported. Cerebrovascular events have been reported in around 3% of patients. In this review we summarize the published literature on cerebrovascular events in patients with COVID-19 as available on the PubMed database. So far, 3 studies have reported cerebrovascular events. Cerebrovascular events were identified on screening patients with decreased consciousness or in the presence of focal neurological deficits. These events were common in elderly, critically ill patients and in patients with prior cardio-cerebrovascular comorbidities. The diagnosis of cerebrovascular events was confirmed with computed tomography of the brain in most studies reporting neurological events. Multiple pathological mechanisms have been postulated regarding the process of neurological and vascular injury among which cytokine storm is shown to correlate with mortality. Patients with severe illness are found to have a higher cardio- cerebrovascular comorbidity. With an increasing number of cases and future prospective studies, the exact mechanism by which these cerebrovascular events occur and attribute to the poor outcome will be better understood.

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Author Biography

Jennifer Sargent, Department of Internal Medicine, St. Vincent Hospital, Worcester; University of Massachusetts Medical School, Worcester, MA

 

 

Published
2020-06-10
Info
Issue
Section
COVID-19 - Collection of articles on the Coronavirus outbreak
Keywords:
COVID-19, cerebrovascular events, imaging, mechanism, outcome
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  • PDF: 249
How to Cite
Mishra, A. K., Sahu, K. K., George, A. A., Sargent, J., & Lal, A. (2020). Cerebrovascular events in COVID-19 patients. Monaldi Archives for Chest Disease, 90(2). https://doi.org/10.4081/monaldi.2020.1341