A case of lung injury resembling diffuse pulmonary hemorrhage after the first administration of alemtuzumab in a patient with multiple sclerosis. Role of the HRCT

https://doi.org/10.4081/monaldi.2020.1352

Authors

  • Gaia Cipolla Pulmonology, AOU Policlinico G. Martino, Messina, Italy.
  • Rosalba Relo Pulmonology, AOU Policlinico G. Martino, Messina, Italy.
  • Elisa Pasciuta Pulmonology, AOU Policlinico G. Martino, Messina, Italy.
  • Domenica Catalano Pulmonology, AOU Policlinico G. Martino, Messina, Italy.
  • Federica Lo Bello Pulmonology, AOU Policlinico G. Martino, Messina, Italy. https://orcid.org/0000-0002-7825-9368
  • Irene Coppolino Pulmonology, AOU Policlinico G. Martino, Messina, Italy. https://orcid.org/0000-0003-1707-8958
  • Paolo Ruggeri Pulmonology, AOU Policlinico G. Martino, Messina, Italy. https://orcid.org/0000-0003-0379-9869
  • Alfio Proietto Pulmonology, AOU Policlinico G. Martino, Messina, Italy. https://orcid.org/0000-0003-0154-4088
  • Maria Buccafusca Neurology, AOU Policlinico G. Martino, Messina, Italy.
  • Paola Maria Cutroneo Sicilian Regional Pharmacovigilance Centre, AOU Policlinico G. Martino, Messina, Italy. https://orcid.org/0000-0002-6937-4495
  • Gianluca Trifirò Sicilian Regional Pharmacovigilance Centre, AOU Policlinico G. Martino, Messina, Italy. https://orcid.org/0000-0003-1147-7296
  • Gaetano Caramori | gcaramori@unime.it Pulmonology, AOU Policlinico G. Martino, Messina, Italy. https://orcid.org/0000-0002-9807-327X

Abstract

Diffuse alveolar hemorrhage (DAH) is an acute often life-threatening condition characterized by a variable combination of hemoptysis, dyspnoea, diffuse and bilateral ground glass pulmonary opacities, anemia and hypoxemia, that can be induced by different causes, including several drugs. We report here the case of a 25-year-old woman who has been admitted to our pulmonary clinic for the onset of chest pain, cough and haemoptysis, started one week after her first treatment with alemtuzumab for multiple sclerosis. Computed tomography (CT) scan of the chest at the admission showed diffuse and bilateral ground glass pulmonary opacities. Her symptoms resolved completely without any treatment, after the interruption of alemtuzumab, and CT scan of the chest performed one month later showed total disappearance of the pulmonary opacities.

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Published
2020-07-24
Info
Issue
Section
Pneumology - Case Reports
Keywords:
diffuse pulmonary haemorrhage, multiple sclerosis, alemtuzumab, adverse drug reaction
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How to Cite
Cipolla, Gaia, Rosalba Relo, Elisa Pasciuta, Domenica Catalano, Federica Lo Bello, Irene Coppolino, Paolo Ruggeri, Alfio Proietto, Maria Buccafusca, Paola Maria Cutroneo, Gianluca Trifirò, and Gaetano Caramori. 2020. “A Case of Lung Injury Resembling Diffuse Pulmonary Hemorrhage After the First Administration of Alemtuzumab in a Patient With Multiple Sclerosis. Role of the HRCT”. Monaldi Archives for Chest Disease 90 (3). https://doi.org/10.4081/monaldi.2020.1352.

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