ATHerosclerosis of the lower extremIties as a liNKed comorbidity in Patients Admitted for carDiac rehabilitation (THINKPAD): rationale, design, and study group


  • Marco Ambrosetti | U.O. Cardiologia e Angiologia Riabilitativa, Clinica Le Terrazze, Cunardo (VA), Italy.
  • Tommaso Diaco Divisione di Cardiologia Riabilitativa, A.O. di Crema, Presidio Ospedaliero di Rivolta d’Adda, Italy.
  • Oreste Febo Divisione di Cardiologia, IRCCS Fondazione S. Maugeri, Istituto Scientifico di Montescano (PV), Italy.
  • Pasqualina Calisi Divisione di Cardiologia Riabilitativa, Ospedale La Colletta, Arenzano (GE), Italy.
  • Giuseppe Favretto U.O. di Cardiologia Riabilitativa e Preventiva, Ospedale Riabilitativo di Alta Specializzazione s.p.a di Motta di Livenza (TV), Italy.
  • Roberto Carlon Divisione di Cardiologia, Ospedale di Cittadella (PD), Italy.
  • Pier Luigi Temporelli Divisione di Cardiologia, IRCCS Fondazione S. Maugeri, Veruno (NO), Italy.


Peripheral arterial disease (PAD) is a frequent comorbidity among patients entering cardiac rehabilitation (CR) programmes and an important source of disability and impaired prognosis. The prevalence of PAD across the wide range of conditions for CR is poorly understood, as far as its impact on drug optimization and intervention delivered. The “ATHerosclerosis of the lower extremIties as a liNKed comorbidity in Patients Admitted for carDiac rehabilitation†(THINKPAD) study was carried out by the Italian Association for Cardiovascular Prevention, Rehabilitation and Epidemiology (GICR-IACPR) in order to explore PAD both as a comorbidity and a primary indication at the entry of CR. The study was a retrospective case series. In the study period (from May 1, 2012 to June 30, 2012), data on consecutive patients discharged from 17 CR units in Northern Italy were collected. Web-based electronic case report forms (e-CRF), accessible in a dedicated section of the IACPR website (, were used for data entry, and data were transferred via web to a central database. The data collection instrument was designed with a multiple choice format, with jump menus or select boxes and obligatory items. A sample size of 1,300 subjects is expected, with first data available by the end of 2012.



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Study Protocol
peripheral arterial disease, rehabilitation, registry
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How to Cite
Ambrosetti, Marco, Tommaso Diaco, Oreste Febo, Pasqualina Calisi, Giuseppe Favretto, Roberto Carlon, and Pier Luigi Temporelli. 2015. “ATHerosclerosis of the Lower ExtremIties As a LiNKed Comorbidity in Patients Admitted for CarDiac Rehabilitation (THINKPAD): Rationale, Design, and Study Group”. Monaldi Archives for Chest Disease 78 (1).

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