Essential amino acid supplementation in patients with severe COPD: a step towards home rehabilitation

https://doi.org/10.4081/monaldi.2012.154

Authors

  • R.W. Dal Negro U.O.C. di Pneumologia, ULSS22 Regione Veneto, Ospedale Orlandi, Bussolengo, Verona, Italy.
  • A. Testa Riabilitazione CardioPneumologica Ospedale Ettore Spalenza, Fondazione Don Gnocchi, Rovato, Brescia, Italy.
  • R. Aquilani Servizio di Fisiopatologia Metabolico-Nutrizionale e Nutrizione Clinica, Fondazione S. Maugeri, IRCCS, Istituto Scientifico di Montescano, Pavia, Italy.
  • S. Tognella U.O.C. di Pneumologia, ULSS22 Regione Veneto, Ospedale Orlandi, Bussolengo, Verona, Italy.
  • E. Pasini Fondazione S. Maugeri, IRCCS, Istituto Scientifico di Lumezzane, Brescia, Italy.
  • A. Barbieri Dipartimento di Scienze del Farmaco, Università degli Studi di Pavia, Pavia, Italy.
  • F. Boschi | federica.boschi@unipv.it Dipartimento di Scienze del Farmaco, Università degli Studi di Pavia, Pavia, Italy.

Abstract

Background. Pulmonary Rehabilitation (“Rehabilitationâ€) can improve both lung function and quality of life in patients suffering from chronic obstructive pulmonary disease (COPD) even if only a very small proportion of patients have access to Rehabilitation. Supplementation of Essential Amino Acids (EAAs) might allow COPD patients to achieve some typical Rehabilitation outcomes such as a better physical performance and an improved health status. Methods. 88 COPD out-patients (GOLD class 3-4) with a body mass index (BMI) <23 Kg/m2 were randomised to receive EAAs (n=44) or placebo (n=44) for twelve weeks. Primary outcome measures were changes in both physical activities in daily life (measured by Sense Wear Armband in terms of mean steps walked in one week) and in quality of life (measured by the St George’s Respiratory Questionnaire, SGRQ). Results. After 12 weeks, the physical performance was significantly increased vs baseline only in patients who received EAAs (1140.33 ± 524.69 and 638.68 ± 662.1 steps/day, respectively; p=0.02), being also the comparison vs the placebo group highly significant (p=0.003). Similarly, the SGRQ score improved significantly only in EAA patients (69.35 ± 9.51 vs baseline 72.04 ± 8.62; p<0.01), and changes were significantly different from those measured in the placebo group (p<0.001). Furthermore, when compared to those who received placebo, EAAs patients significantly increased their fat-free mass (p=0.04), muscle strength (p<0.01), saturation of oxygen (p=0.05), serum albumin (p<0.001), and also ameliorated their original cognitive dysfunction (p=0.02). Conclusions. Oral supplementation with EAAs contribute to improve the daily-life performance in domiciliary severe COPD patients who can not enter any Rehabilitation programme, together with their quality of life; nutritional and cognitive status, and muscle strength.

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Published
2015-12-03
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Original Articles
Keywords:
Essential Amino Acids, COPD, Sarcopenia, Physical performance
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  • PDF: 1055
How to Cite
Dal Negro, R.W., A. Testa, R. Aquilani, S. Tognella, E. Pasini, A. Barbieri, and F. Boschi. 2015. “Essential Amino Acid Supplementation in Patients With Severe COPD: A Step towards Home Rehabilitation”. Monaldi Archives for Chest Disease 77 (2). https://doi.org/10.4081/monaldi.2012.154.

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