SARS-CoV-2 related pneumonia in an adult with cystic fibrosis: natural favourable clinical course or effective therapy?

https://doi.org/10.4081/monaldi.2020.1579

Authors

  • Maddalena Giglia | maddalena.giglia@studio.unibo.it Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna, Italy. https://orcid.org/0000-0002-3838-4041
  • Giacomo Beci Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna, Italy. https://orcid.org/0000-0001-8528-3924
  • Elena Rosselli Del Turco Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna, Italy. https://orcid.org/0000-0002-9059-4804
  • Viola Guardigni Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna, Italy. https://orcid.org/0000-0002-2769-7325
  • Alberto Amedeo Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna, Italy. https://orcid.org/0000-0003-3787-0846
  • Giulia Cucchetto Cystic Fibrosis Regional Centre, AOUI Verona, Italy.
  • Gabriella Verucchi Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna, Italy.
  • Marco Cipolli Cystic Fibrosis Regional Centre, AOUI Verona, Italy. https://orcid.org/0000-0001-5652-7248
  • Leonardo Calza Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna, Italy.
  • Pierluigi Viale Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna, Italy.

Abstract

We report the case of a man affected by cystic fibrosis who developed a severe SARS-CoV-2 related pneumonia in March 2020. In addition to lopinavir/ritonavir and hydroxychloroquine, he was treated with two doses of tocilizumab, displaying a significant clinical improvement. This is the first case described in the literature of an adult patient affected by cystic fibrosis who received tocilizumab for COVID-19, with documented total recovery, also assessed by a spirometry.

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Published
2020-12-23
Info
Issue
Section
COVID-19 - Collection of articles on the Coronavirus outbreak
Keywords:
COVID-19, tocilizumab, cystic fibrosis
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How to Cite
Giglia, Maddalena, Giacomo Beci, Elena Rosselli Del Turco, Viola Guardigni, Alberto Amedeo, Giulia Cucchetto, Gabriella Verucchi, Marco Cipolli, Leonardo Calza, and Pierluigi Viale. 2020. “SARS-CoV-2 Related Pneumonia in an Adult With Cystic Fibrosis: Natural Favourable Clinical Course or Effective Therapy?”. Monaldi Archives for Chest Disease 90 (4). https://doi.org/10.4081/monaldi.2020.1579.