Management and outcomes of patients hospitalized with severe COVID-19 at a tertiary care center in midwestern United States

  • Sandeep Gupta | sandynoida@gmail.com Division of Pulmonary, Critical Care and Sleep Medicine, Unity Point Health at St. Luke’s Regional Medical Center, Sioux City, IA, United States.
  • Ashlesha Kaushik Pediatric Infectious Diseases, Unity Point Health at St. Luke's Regional Medical Center, Sioux City, IA, United States.
  • Jitendra Gupta Division of Pulmonary, Critical Care and Sleep Medicine, Unity Point Health at St. Luke’s Regional Medical Center, Sioux City, IA, United States.

Abstract

Knowledge of treatment regimens and outcomes for novel coronavirus disease 2019 (COVID-19) is evolving. Recent studies have reported mortality rates ranging from 39-50% among hospitalized patients with COVID-19. We report our experience ofmanagement and outcomes of hospitalized patients with COVID-19 at a large tertiary-care center in Midwestern United States. Of 658 patients presenting to our tertiary care center, 217 needed hospitalization, majority (77%) of whom were severely sick requiring admission to the intensive care unit (ICU). All received corticosteroids, and 78% of the patients received tocilizumab. More than two-thirds of the patients received anticoagulation and 80% of patients in the ICU had prone-positioning. The median duration of hospitalization was 12 days (interquartile range, 8 to16), median duration of intensive care unit stay was 7 days (interquartile range, 5 to 9) and requirement of mechanical ventilation was 6 days (interquartile range, 5 to 8) in our cohort. Of the 217 patients, 27 died (12% mortality). The majority of our patients received corticosteroids, tocilizumab, anticoagulation and prone positioning. While higher mortality rates of >30% have been reported in various studies among hospitalized patients with COVID-19, the majority of hospitalized patients in our cohort survived with a low mortality rate. The majority of our patients received corticosteroids, tocilizumab, anticoagulation and prone positioning. While higher mortality rates of >30% have been reported in various studies among hospitalized patients with COVID-19, the majority of hospitalized patients in our cohort survived with a low mortality rate.

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Author Biography

Ashlesha Kaushik, Pediatric Infectious Diseases, Unity Point Health at St. Luke's Regional Medical Center, Sioux City, IA

Medical Director, COVID-19 Incident Command; University of Iowa Carver College of Medicine

 

Published
2020-10-08
Info
Issue
Section
COVID-19 - Collection of articles on the Coronavirus outbreak
Keywords:
Outcomes, hospitalized, management, SARS-CoV-2, COVID-19
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How to Cite
Gupta, S., Kaushik, A., & Gupta, J. (2020). Management and outcomes of patients hospitalized with severe COVID-19 at a tertiary care center in midwestern United States. Monaldi Archives for Chest Disease, 90(4). https://doi.org/10.4081/monaldi.2020.1592