Home physiotherapists assisting follow-up treatment in cystic fibrosis: a multicenter observational study



  • Anna Brivio Cystic Fibrosis Centre and U.O.C. Direzione delle Professioni Sanitarie, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan , Italy.
  • Annalisa Orenti Department of Clinical Sciences and Community Health, Laboratory of Medical Statistics, Epidemiology and Biometry G. A. Maccacaro, University of Milan, Italy. https://orcid.org/0000-0002-0932-2757
  • Mauro Barbisan UOS Fibrosi Cistica, Hospital S. Maria di Ca' Foncello, Treviso, Italy.
  • Paolo Buonpensiero Department of Translational Medical Sciences, Cystic Fibrosis Centre, Federico II University of Naples, Italy. https://orcid.org/0000-0002-4497-1904
  • Mirco Ros UOS Fibrosi Cistica, Hospital S. Maria di Ca' Foncello, Treviso, Italy.
  • Simone Gambazza | simone.gambazza@policlinico.mi.it Cystic Fibrosis Centre, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan; 3Department of Clinical Sciences and Community Health, Laboratory of Medical Statistics, Epidemiology and Biometry G. A. Maccacaro, University of Milan , Italy. https://orcid.org/0000-0002-6225-2989


Inhaled therapies are relatively simple and easy to be managed however ineffective use of aerosols when self-administered may occur. We described variation of the number of clinic visits, lung function and number of antibiotic courses performed over 12 months in participants with cystic fibrosis (CF), when supervised or not by physiotherapists (PTs) at home. Participants in 8 Italian CF centers with a prescription of dry-powder antibiotic choose whether to be supervised at home (PT-FU) or not (non-PT-FU), in adjunct to routine clinic visits. PTs assisted participants with their inhaled therapies regimen and reviewed the airway clearance program in use.  Mixed-effect regression models were fitted to evaluate the variation of selected endpoints over time. A total of 163 participants were included.  Lung function declined over time in both groups, at higher extent in the non-PT-FU group at 6 months (-1.8, 95%CI: -4.4 to 0.7 % predicted), without reaching statistical significance, whereas in the PT-FU group only, nearly one visit less was recorded (p=0.027). Regardless the type of supervision adopted, the number of antibiotic courses did not change compared to the previous year. We counted 19/90 (21.1%) drop-out in the PT-FU, double compared to the group followed up at the clinics (p=0.065). Participants under a course of an inhaled antibiotic therapy showed a 1-year decline in lung function, whereas only the group receiving home supervision counted nearly one visit less at the CF center, whose clinical relevance should be further discussed.



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Physiotherapy - Original Articles
physiotherapy, home visit, aerosol, cystic fibrosis
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How to Cite
Brivio, Anna, Annalisa Orenti, Mauro Barbisan, Paolo Buonpensiero, Mirco Ros, and Simone Gambazza. 2021. “Home Physiotherapists Assisting Follow-up Treatment in Cystic Fibrosis: A Multicenter Observational Study”. Monaldi Archives for Chest Disease 91 (2). https://doi.org/10.4081/monaldi.2021.1619.