https://doi.org/10.4081/monaldi.2021.1624

Clinico-radiological profile of connective tissue disease related-interstitial lung diseases from a tertiary care centre of India: a cross sectional study

Vol. 91 No. 4 (2021)
Submitted: September 26, 2020
Accepted: March 22, 2021
Published: April 2, 2021
Connective tissue diseases, interstitial lung diseases, spirometry, HRCT thorax, prognosis
Abstract Views: 3544
PDF: 973
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Authors

Mehul Agarwal
Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Manohar Lal Gupta
Department of Pulmonary Medicine, Santokba Durlabhji Memorial Hospital, Jaipur, India.
Kunal Deokar
Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Benhur Joel Shadrach
benjoe6326@gmail.com
https://orcid.org/0000-0002-2314-2306
Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Neha Bharti
Department of Anaesthesia and Critical Care, All India Institute of Medical Sciences, Jodhpur, India.
Maldev Sonigra
Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur, India.

Interstitial lung diseases (ILDs) are a frequently occurring pulmonary manifestation in patients of connective tissue diseases (CTD). Detailed understanding of this subset of lung diseases is vital, hence the study was conducted to analyze the clinico-radiological characteristics of CTD-ILD. The present study was conducted between March 2017 to February 2018 at a tertiary care teaching hospital from western India. A total of 100 patients having respiratory symptoms suggestive of ILD, who were either diagnosed cases of CTD or had clinical manifestations of underlying CTD, were included in the study.  27% of patients belonged to age group 41-50 years and 78% were females. Chief respiratory complaints were dyspnea and cough. Clubbing was present in 29% patients. The most common CTDs were rheumatoid arthritis [RA] (26%), systemic sclerosis [SSC] (21%), mixed connective tissue disorder [MCTD] (19%) and Sjogren’s syndrome [SS] (16%). Restrictive defect on spirometry was seen in 58% cases and was most significant among patients with RA (65%) and SS (62%). Pulmonary arterial hypertension was seen in 40% cases and was most evident in MCTD (78%) and SSC patients (58%). Chest radiograph was normal in 47% of subjects. Most common radiological pattern on high resolution computed tomography (HRCT) thorax was non-specific interstitial pneumonia (42%) followed by usual interstitial pneumonia (21%). ILD is a common manifestation of CTD. Work-up for an underlying CTD should be offered to all ILD patients and vice versa.

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How to Cite

Agarwal, Mehul, Manohar Lal Gupta, Kunal Deokar, Benhur Joel Shadrach, Neha Bharti, and Maldev Sonigra. 2021. “Clinico-Radiological Profile of Connective Tissue Disease Related-Interstitial Lung Diseases from a Tertiary Care Centre of India: A Cross Sectional Study”. Monaldi Archives for Chest Disease 91 (4). https://doi.org/10.4081/monaldi.2021.1624.
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