Comparative studies of dual bronchodilation in COPD
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Accepted: December 11, 2020
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Authors
Dual bronchodilation therapy is becoming the cornerstone for the treatment of COPD because the clinical benefits of LABA/LAMA fixed-dose combinations (FDCs) are now extensively established. Therefore, it not surprising that a number of LAMA/LABA combinations in a single inhaler have now been approved for clinical use as treatments for patients with COPD. Regrettably, very few head-to-head studies between all of the available LABA/LAMA FDCs have been carried out. This makes choosing the most appropriate FDC difficult. Comparative effectiveness research that also uses conventional meta-analyses to compare different care strategies can help generate useful information. A bidimensional comparative analysis across LAMA/LABA FDCs has suggested constant superiority for tiotropium/olodaterol. However, considering that there is not an equivalent amount of evidence on efficacy outcomes for all LAMA/LABA FDCs, a proper comparison between the different LAMA/LABA FDCs cannot be made yet, and the information available is still rather inconsistent.
Ethics Approval
MC reports grants and personal fees from Almirall, Boehringer Ingelheim, Novartis, and Zambon and personal fees from ABC Farmaceutici, AstraZeneca, Biofutura, Chiesi Farmaceutici, Cipla, Edmond Pharma, GlaxoSmithKline, Lallemand, Menarini, Mundipharma, Ockham Biotech, Pfizer, Sanofi, and Verona Pharma, outside the submitted work. MGM reports grants and personal fees from GlaxoSmithKline, and Novartis and personal fees from ABC Farmaceutici, AstraZeneca, and Chiesi Farmaceutici, outside the submitted work. PR reports grants and personal fees from Almirall, Boehringer Ingelheim, Chiesi Farmaceutici, Novartis and Zambon, and personal fees from AstraZeneca, Biofutura, Edmond Pharma, GlaxoSmithKline, and Sanofi, outside the submitted work. LC reports grants and personal fees from Boehringer Ingelheim, and Novartis, grants from Chiesi Farmaceutici, personal fees from ABC Farmaceutici, Edmond Pharma, Ockham Biotech, Verona Pharma and Zambon, grants from Almirall, and non-financial support from AstraZeneca, outside the submitted workHow to Cite
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