Cytomegalovirus pneumonia in an immunocompetent host with primary ciliary dyskinesia: A case report

https://doi.org/10.4081/monaldi.2021.1638

Authors

  • Vasiliki Epameinondas Georgakopoulou | vaso_georgakopoulou@hotmail.com Pulmonology Department, Laiko General Hospital, Athens, Greece. https://orcid.org/0000-0003-0772-811X
  • Dimitrios Mermigkis 1st Pulmonology Department Sismanogleio Hospital, Athens, Greece.
  • Despoina Melemeni 1st Pulmonology Department Sismanogleio Hospital, Athens, Greece.
  • Aikaterini Gkoufa First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Christos Damaskos Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Nikolaos Garmpis Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Anna Garmpi First Department of Propedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. https://orcid.org/0000-0003-0258-5965
  • Nikolaos Trakas Biochemistry Department, Sismanogleio Hospital, Athens, Greece.
  • Xanthi Tsiafaki 1st Pulmonology Department Sismanogleio Hospital, Athens, Greece.

Abstract

Primary ciliary dyskinesia (PCD) is an autosomal-recessive inherited disease caused by mutations in genes involved in ciliary structure and function leading to impaired mucociliary clearance and repeated or chronic, usually bacterial, infections of the upper and lower airways and decreased lung function and bronchiectasis. Cytomegalovirus (CMV) is a DNA virus that usually causes subclinical infection and in 10% of the patients causes a mononucleosis-like syndrome. CMV is a causative agent of serious illness in vulnerable immunocompromised groups such as transplant recipients, patients with immunodeficiency or malignancy and neonates. Life-threatening infection due to CMV, including CMV pneumonia, is not common in immunocompetent patients. In this report we describe a case of an otherwise immunocompetent woman, suffering from PCD, who developed severe CMV pneumonia.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

References

Knowles MR, Zariwala M, Leigh M. Primary Ciliary Dyskinesia. Clin Chest Med 2016;37:449-61. DOI: https://doi.org/10.1016/j.ccm.2016.04.008

Lucas JS, Barbato A, Collins SA. European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia. Eur Respir J 2017;49:1601090. DOI: https://doi.org/10.1183/13993003.01090-2016

Shapiro AJ, Zariwala MA, Ferkol T, et al. Diagnosis monitoring and treatment of primary ciliary dyskinesia: PCD Foundation consensus recommendations based on state of the art review. Pediatr Pulmonol 2016;51:115-32. DOI: https://doi.org/10.1002/ppul.23304

Grilli E, Galati V, Bordi L, et al. Cytomegalovirus pneumonia in immunocompetent host: case report and literature review. J Clin Viro. 2012;55:356-9. DOI: https://doi.org/10.1016/j.jcv.2012.08.010

Klemola E, Stenstrom R, von Essen R. Pneumonia as a clinical manifestation of cytomegalovirus infection in previously healthy adults. Scand J Infect Dis 1972;4:7-10. DOI: https://doi.org/10.3109/inf.1972.4.issue-1.02

Manian FA, Smith T. Ganciclovir for the treatment of cytomegalovirus pneumonia in an immunocompetent host. Clin Infect Dis 1993;17:137–8. DOI: https://doi.org/10.1093/clinids/17.1.137-a

Halimi C, Hajeje H, Mouchet M, et al. [CMV lung infection in a non-mmunocompromised patients treated with ganciclovir].[Article in French]. Ann Med Intern 1993;144:502–4.

EddlestonM, Peacock S, JuniperM, et al. Severe cytomegalovirus infection in immunocompetent patients. Clin Infect Dis 1997;24:52–6. DOI: https://doi.org/10.1093/clinids/24.1.52

McCormack JG, Bowler SD, Donnelly JE, et al. Successful treatment of severe cytomegalovirus infection with ganciclovir in an immunocompetent host. Clin Infect Dis 1998;26:1007–8. DOI: https://doi.org/10.1086/517635

Karakelides H, Aubry MC, Ryu JH. Cytomegalovirus pneumonia mimicking lung cancer in an immunocompetent host. Mayo Clin Proc 2003;78:488–90. DOI: https://doi.org/10.4065/78.4.488

Abgueguen P, Delbos V, Chennebault JM, et al. Vascular thrombosis and acute cytomegalovirus infection in immunocompetent patients: report of 2 cases and literature review. Clin Infect Dis 2003;36:E134-9. DOI: https://doi.org/10.1086/374664

Cunha BA, Pherez F, Walls N. Severe cytomegalovirus (CMV) community-acquired pneumonia (CAP) in a nonimmunocompromised host. Heart Lung 2009;38:243-8. DOI: https://doi.org/10.1016/j.hrtlng.2008.05.008

Barclay A, Naseer R, McGann H, et al. Cytomegalovirus pneumonia in an immunocompetent adult: a case report. Acute Med 2011;10:197–9.

Ii K, Hizama K, Katuses R. Generalized cytomegalic inclusion disease presenting as an infectious mononucleosis syndrome in a previously healthy adult-an autopsy study. Acta Pathol Jpn 1972;22:723–37.

Back E, Hoglunf C, Malmlund HO. Cytomegalovirus infection associated with severe encephalitis. Scand J Infect Dis 1977;9:141–3. DOI: https://doi.org/10.3109/inf.1977.9.issue-2.17

Teixidor HS, Honig CL, Norsoph E, et al. Cytomegalovirus infection of the alimentary canal: radilogical findings with pathologic correlation. Radiology 1987;163:317-23. DOI: https://doi.org/10.1148/radiology.163.2.3031723

Alanin MC, Nielsen KG, von Buchwald C, et al. A longitudinal study of lung bacterial pathogens in patients with primary ciliary dyskinesia. Clin Microbiol Infect 2015;21:1093.e1-7. DOI: https://doi.org/10.1016/j.cmi.2015.08.020

Wijers CD, Chmiel JF, Gaston BM. Bacterial infections in patients with primary ciliary dyskinesia: Comparison with cystic fibrosis. Chron Respir Dis 2017;14:392-406. DOI: https://doi.org/10.1177/1479972317694621

Roden L, Görlich D, Omran H, et al. A retrospective analysis of the pathogens in the airways of patients with primary ciliary dyskinesia. Respir Med 2019;156:69-77. DOI: https://doi.org/10.1016/j.rmed.2019.08.009

Sakhaee F, Vaziri F, Bahramali G, et al. pulmonary infection related to mimivirus in patient with primary ciliary dyskinesia. Emerg Infect Dis 2020;26:2524-6. DOI: https://doi.org/10.3201/eid2610.191613

Downloads

Published
2021-04-22
Info
Issue
Section
Pneumology - Case Reports
Keywords:
CMV infection, pneumonia, primary ciliary dyskinesia
Statistics
  • Abstract views: 344

  • PDF: 128
How to Cite
Georgakopoulou, Vasiliki Epameinondas, Dimitrios Mermigkis, Despoina Melemeni, Aikaterini Gkoufa, Christos Damaskos, Nikolaos Garmpis, Anna Garmpi, Nikolaos Trakas, and Xanthi Tsiafaki. 2021. “Cytomegalovirus Pneumonia in an Immunocompetent Host With Primary Ciliary Dyskinesia: A Case Report”. Monaldi Archives for Chest Disease 91 (3). https://doi.org/10.4081/monaldi.2021.1638.