Sarcoidosis and multiple sclerosis: systemic toxicity associated with the use of interferon-beta therapy

https://doi.org/10.4081/monaldi.2012.165

Authors

  • C. Carbonelli | cristiano.carbonelli@asmn.re.it Pulmonology Unit, Department of Cardiology, Thoracic and Vascular Surgery and Critical Care Medicine, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy.
  • S. Montepietra Neurology Unit, Department of Neuromotor Physiology, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy.
  • A. Caruso Rheumatology Unit, Departement of Internal Medicine, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy.
  • A. Cavazza Pathology Unit, Department of Oncology, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy.
  • C. Feo Neurology Unit, Department of Neuromotor Physiology, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy.
  • F. Menzella Pulmonology Unit, Department of Cardiology, Thoracic and Vascular Surgery and Critical Care Medicine, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy.
  • L. Motti Neurology Unit, Department of Neuromotor Physiology, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy.
  • L. Zucchi Pulmonology Unit, Department of Cardiology, Thoracic and Vascular Surgery and Critical Care Medicine, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy.

Abstract

Sarcoidosis is a multi-systemic inflammatory disease of unknown origin characterized by the presence of noncaseating epitheloid cell granulomas in multiple organs. Diagnosis is made on the basis of a compatible clinical-radiological scenario and the histological demonstration of the typical granulomas in the affected tissues. Interferons are immuno-modulators that have been used in a wide range of diseases, including hepatitis C virus infection, multiple sclerosis, and multiple myeloma and other types of tumours, including leukemia, lymphomas, Kaposi’s sarcoma, and melanoma. Interferon-α-induced sarcoidosis has been reported repeatedly and there are two reports in the literature of cases of pulmonary sarcoidosis treated with interferon-1b therapy: one for advanced renal cell carcinoma and the other for multiple myeloma. A 35-year-old man on chronic immune-modulant Interferon- 1b-based therapy for multiple sclerosis presented to the Neurology Unit with mild dyspnoea, dry cough, and transient pain to right upper abdomen. Lungs, spleen, liver, and almost all lymphnode stations of abdomen and mediastinum were clearly involved on ultrasound examination, chest X-ray, and computed tomography. A transbronchial biopsy showed non-caseating granuloma on histopathologic evaluation of the lungs. To the best of our knowledge, this is the first report of a chronic multisystemic sarcoidosis that was associated with interferon-beta treatment.

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Published
2015-12-03
Info
Issue
Section
Case Reports
Keywords:
Multiple sclerosis, Demyelinating diseases, Neurological disorders, Adverse effects, Medication, Management, Interferons, Sarcoidosis
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  • PDF: 492
How to Cite
Carbonelli, C., S. Montepietra, A. Caruso, A. Cavazza, C. Feo, F. Menzella, L. Motti, and L. Zucchi. 2015. “Sarcoidosis and Multiple Sclerosis: Systemic Toxicity Associated With the Use of Interferon-Beta Therapy”. Monaldi Archives for Chest Disease 77 (1). https://doi.org/10.4081/monaldi.2012.165.

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