Indirect comparison between ferric carboxymaltose and oral iron replacement in heart failure with reduced ejection fraction: a network meta-analysis


  • Edoardo Sciatti | Cardiology Unit, ASST del Garda, Hospital of Desenzano del Garda (BS), Italy.
  • Ugo Nesti Biostatistician, Pencil and Papers, Pisa, Italy.
  • Andrea Di Lenarda Cardiovascular Center, University Hospital and Health Services of Trieste, Italy.


Treatment of iron deficiency (ID) in patients with heart failure (HF) has improved symptoms, quality of life, exercise capacity and has reduced hospitalizations in randomized controlled trials (RCTs) and meta-analyses. Intravenous ferric carboxymaltose (FCM) provided convincing results in this field, while oral iron supplementation failed. However, FCM and oral iron were compared to placebo, and a comparison between the two strategies is still lacking. We aimed to fill this gap of knowledge with an indirect comparison between them by means of a network meta-analysis of RCTs. Five studies measuring exercise capacity (i.e. 6-minute walking test) and quality of life (i.e. Kansas City Cardiomyopathy Questionnaire) were eligible to be included in our review. Given the limitations of a network meta-analysis, our findings support the better efficacy of FCM than oral iron as regards exercise capacity, with a trend towards an improvement in quality of life, suggesting that FCM seems to be strategy of choice to correct ID in HF patients.



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Cardiology - Original Articles
Supporting Agencies
Ferinject, ferric carboxymaltose, quality of life, 6-minute walking test, heart failure.
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How to Cite
Sciatti, Edoardo, Ugo Nesti, and Andrea Di Lenarda. 2021. “Indirect Comparison Between Ferric Carboxymaltose and Oral Iron Replacement in Heart Failure With Reduced Ejection Fraction: A Network Meta-Analysis”. Monaldi Archives for Chest Disease, March.

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