COVID-19: the difference between the nose and the lung


  • Matteo Gelardi Department of Otolaryngology, University of Foggia, Italy.
  • Mario Notargiacomo Otorhinolaryngology Unit, Melzo Hospital, Milan, Italy.
  • Eleonora Maria Consiglia Trecca Department of Otolaryngology, University of Foggia, Italy.
  • Michele Cassano Department of Otolaryngology, University of Foggia, Italy.
  • Giorgio Ciprandi | Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.


To the Editor

An elegant study reported dysmorphic cells and syncytia in the deceased's lungs for COVID-19. The authors reasonably considered that most of these syncytia-forming cells were pneumocytes, as identified by specific biomarkers. However, cellular dysmorphism and syncytia are pathological features common in other respiratory infections caused by different viruses, including the human respiratory syncytial virus (HRSV) and Epstein-Barr virus (EBV), as correctly documented... 



PlumX Metrics


Download data is not yet available.


Bussani R, Schneider E, Zentilin L, et al. Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology. EBioMedicine 2020;61:103104. DOI:

Gagliardi TB, Ferreira Criado M, Proenca-Modena JL, et al. Syncytia induction by clinical isolates of human respiratory syncytial virus A. Intervirology 2017;60:56-60. DOI:

Gelardi M, Tomaiuolo M, Cassano M, et al. Epstein-Barr virus induced cellular changes in nasal mucosa. Virology J 2006;3:6. DOI:

Gelardi M, Ciprandi G. Ciliocytophthoria of nasal epithelial cells after viral infection: a sign of suffering cell. Acta Biomed 2019;90:7-9.

Gelardi M, Notargiacomo M, Trecca EMC, Cassano M. SARS-CoV-2: Naso-bronchial cytological correlations. Am J Otolaryngol 2020;41:102549. DOI:


COVID-19 - Collection of articles on the Coronavirus outbreak
COVID-19, nose, bronchi, lung, epithelial cell
  • Abstract views: 430

  • PDF: 169
How to Cite
Gelardi, Matteo, Mario Notargiacomo, Eleonora Maria Consiglia Trecca, Michele Cassano, and Giorgio Ciprandi. 2021. “COVID-19: The Difference Between the Nose and the Lung”. Monaldi Archives for Chest Disease 91 (2).