COVID-19: the difference between the nose and the lung
https://doi.org/10.4081/monaldi.2021.1708
Authors
- Matteo Gelardi Department of Otolaryngology, University of Foggia, Italy.
- Mario Notargiacomo Otorhinolaryngology Unit, Melzo Hospital, Milan, Italy.
- Eleonora Maria Consiglia Trecca Department of Otolaryngology, University of Foggia, Italy. https://orcid.org/0000-0001-6490-1746
- Michele Cassano Department of Otolaryngology, University of Foggia, Italy.
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Giorgio Ciprandi
|
gio.cip@libero.it
Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.
https://orcid.org/0000-0001-7016-8421
Abstract
To the Editor
An elegant study reported dysmorphic cells and syncytia in the deceased's lungs for COVID-19. The authors reasonably considered that most of these syncytia-forming cells were pneumocytes, as identified by specific biomarkers. However, cellular dysmorphism and syncytia are pathological features common in other respiratory infections caused by different viruses, including the human respiratory syncytial virus (HRSV) and Epstein-Barr virus (EBV), as correctly documented...
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References
Bussani R, Schneider E, Zentilin L, et al. Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology. EBioMedicine 2020;61:103104. DOI: https://doi.org/10.1016/j.ebiom.2020.103104
Gagliardi TB, Ferreira Criado M, Proenca-Modena JL, et al. Syncytia induction by clinical isolates of human respiratory syncytial virus A. Intervirology 2017;60:56-60. DOI: https://doi.org/10.1159/000480014
Gelardi M, Tomaiuolo M, Cassano M, et al. Epstein-Barr virus induced cellular changes in nasal mucosa. Virology J 2006;3:6. DOI: https://doi.org/10.1186/1743-422X-3-6
Gelardi M, Ciprandi G. Ciliocytophthoria of nasal epithelial cells after viral infection: a sign of suffering cell. Acta Biomed 2019;90:7-9.
Gelardi M, Notargiacomo M, Trecca EMC, Cassano M. SARS-CoV-2: Naso-bronchial cytological correlations. Am J Otolaryngol 2020;41:102549. DOI: https://doi.org/10.1016/j.amjoto.2020.102549
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