Lipid-lowering therapy in high cardiovascular risk patients during COVID-19 pandemic: keep focused on the target

https://doi.org/10.4081/monaldi.2021.1721

Authors

  • Arturo Cesaro Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples; Division of Clinical Cardiology, A.O.R.N. “Sant’Anna e San Sebastiano”, Caserta, Italy. https://orcid.org/0000-0003-4435-1235
  • Carmine Riccio Division of Clinical Cardiology, A.O.R.N. “Sant’Anna e San Sebastiano”, Caserta, Italy. https://orcid.org/0000-0003-0160-3674
  • Paolo Calabrò | paolo.calabro@unicampania.it Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples; Division of Clinical Cardiology, A.O.R.N. “Sant’Anna e San Sebastiano”, Caserta, Italy. https://orcid.org/0000-0002-5018-830X

Abstract

To the Editor

COVID-19 (COrona VIrus Disease) patients with cardiovascular (CV) disease, multiple CV risk factors or comorbidities (i.e., arterial hypertension and diabetes) were shown to be more prone to a worse prognosis. SARS-CoV-2 is a still unknown enemy and the role of concomitant cardiovascular therapies has been controversial in the early stages, particularly with regard to Angiotensin-Converting Enzyme inhibitors...

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References

Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020;323:1239-42. DOI: https://doi.org/10.1001/jama.2020.2648

Fedson DS. Treating influenza with statins and other immunomodulatory agents. Antiviral Res 2013;99:417–35. DOI: https://doi.org/10.1016/j.antiviral.2013.06.018

Frost FJ, Petersen H, Tollestrup K, Skipper B. Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins. Chest 2007;131:1006-12. DOI: https://doi.org/10.1378/chest.06-1997

Douglas I, Evans S, Smeeth L. Effect of statin treatment on short term mortality after pneumonia episode: cohort study. BMJ 2011;342:d1642. DOI: https://doi.org/10.1136/bmj.d1642

Shrivastava-Ranjan P, Flint M, Bergeron É, et al. Statins suppress Ebola virus infectivity by interfering with glycoprotein processing. mBio 2018;9:e00660-18. DOI: https://doi.org/10.1128/mBio.00660-18

Yuan S. Statins may decrease the fatality rate of middle east respiratory syndrome infection. mBio 2015;6:e01120. DOI: https://doi.org/10.1128/mBio.01120-15

Gupta A, Madhavan M V, Poterucha TJ, et al. Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19. Res Sq 2020; rs.3.rs-56210. Preprint DOI: https://doi.org/10.21203/rs.3.rs-56210/v1

Fan Y, Guo T, Yan F, et al. Association of statin use with the in-hospital outcomes of 2019-coronavirus disease patients: A retrospective study. Front Med (Lausanne) 2020;7:584870. DOI: https://doi.org/10.3389/fmed.2020.584870

Zhang X-J, Qin J-J, Cheng X, et al. In-hospital use of statins is associated with a reduced risk of mortality among individuals with COVID-19. Cell Metab 2020;32:176-87.e4. DOI: https://doi.org/10.1016/j.cmet.2020.06.015

Saeed O, Castagna F, Agalliu I, et al. Statin use and inâ€hospital mortality in diabetics with COVIDâ€19. J Am Heart Assoc 2020;9:e018475. DOI: https://doi.org/10.1161/JAHA.120.018475

Song SL, Hays SB, Panton CE, et al. Statin use is associated with decreased risk of invasive mechanical ventilation in COVID-19 patients: A preliminary study. Pathogens 2020;9:759. DOI: https://doi.org/10.3390/pathogens9090759

Daniels LB, Sitapati AM, Zhang J, et al. Relation of statin use prior to admission to severity and recovery among COVID-19 inpatients. Am J Cardiol 2020;136:149-55. DOI: https://doi.org/10.1016/j.amjcard.2020.09.012

Butt JH, Gerds TA, Schou M, et al. Association between statin use and outcomes in patients with coronavirus disease 2019 (COVID-19): a nationwide cohort study. BMJ Open 2020;10:e044421. DOI: https://doi.org/10.1136/bmjopen-2020-044421

Cariou B, Goronflot T, Rimbert A, et al. Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO study. Diabetes Metab 202;101202. DOI: https://doi.org/10.1016/j.diabet.2020.10.001

Kow CS, Hasan SS. Meta-analysis of effect of statins in patients with COVID-19. Am J Cardiol 2020;134:153–5. DOI: https://doi.org/10.1016/j.amjcard.2020.08.004

Hariyanto TI, Kurniawan A. Statin therapy did not improve the in-hospital outcome of coronavirus disease 2019 (COVID-19) infection. Diabetes Metab Syndr Clin Res Rev 2020;14:1613–5. DOI: https://doi.org/10.1016/j.dsx.2020.08.023

Scheen AJ. Statins and clinical outcomes with COVID-19: Meta-analyses of observational studies. Diabetes Metab 2020;47:101220. DOI: https://doi.org/10.1016/j.diabet.2020.101220

Bikdeli B, Talasaz AH, Rashidi F, et al. Intermediate versus standard-dose prophylactic anticoagulation and statin therapy versus placebo in critically-ill patients with COVID-19: Rationale and design of the INSPIRATION/INSPIRATION-S studies. Thromb Res 2020;196:382–94. DOI: https://doi.org/10.1016/j.thromres.2020.09.027

Cesaro A, Bianconi V, Gragnano F, et al. Beyond cholesterol metabolism: The pleiotropic effects of proprotein convertase subtilisin/kexin type 9 (PCSK9). Genetics, mutations, expression, and perspective for longâ€term inhibition. Biofactors 2020;46:367-80. DOI: https://doi.org/10.1002/biof.1619

Iqbal Z, Ho JH, Adam S, et al. Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UK. Atherosclerosis 2020;313:126-36. DOI: https://doi.org/10.1016/j.atherosclerosis.2020.09.008

Mureddu GF, Ambrosetti M, Venturini E, et al. Cardiac rehabilitation activities during the COVID-19 pandemic in Italy. Position Paper of the AICPR (Italian Association of Clinical Cardiology, Prevention and Rehabilitation). Monaldi Arch Chest Dis 2020;90:1439. DOI: https://doi.org/10.4081/monaldi.2020.1439

Gragnano F, Natale F, Concilio C, et al. Adherence to proprotein convertase subtilisin/kexin 9 inhibitors in high cardiovascular risk patients: An Italian single-center experience. J Cardiovasc Med 2018;19:75–7. DOI: https://doi.org/10.2459/JCM.0000000000000611

Cesaro A, Gragnano F, Fimiani F, et al. Impact of PCSK9 inhibitors on the quality of life of patients at high cardiovascular risk. Eur J Prev Cardiol 2020;27:556-8. DOI: https://doi.org/10.1177/2047487319839179

Kotseva K, De Backer G, De Bacquer D, et al. Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27 countries: Results from the European Society of Cardiology ESC-EORP EUROASPIRE V registry. Eur J Prev Cardiol 2019;26:824-35. DOI: https://doi.org/10.1177/2047487318825350

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Published
2021-05-04
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Issue
Section
Letters to the Editor
Keywords:
COVID-19, lipid lowering therapy, statin, PCSK9, Coronavirus, cardiac rehabilitation, dyslipidemia
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How to Cite
Cesaro, Arturo, Carmine Riccio, and Paolo Calabrò. 2021. “Lipid-Lowering Therapy in High Cardiovascular Risk Patients During COVID-19 Pandemic: Keep Focused on the Target”. Monaldi Archives for Chest Disease 91 (2). https://doi.org/10.4081/monaldi.2021.1721.

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