Epicardial adipose tissue and insulin resistance in patients with coronary artery disease with or without left ventricular dysfunction

  • Samuele Baldasseroni | pesine@libero.it Department of Clinical and Experimental Medicine, Geriatric Cardiology and Medicine Unit, University of Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Alessandra Pratesi Department of Clinical and Experimental Medicine, Geriatric Cardiology and Medicine Unit, University of Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Francesco Orso Department of Clinical and Experimental Medicine, Geriatric Cardiology and Medicine Unit, University of Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Claudia Di Serio Department of Clinical and Experimental Medicine, Geriatric Cardiology and Medicine Unit, University of Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Alice Foschini Department of Clinical and Experimental Medicine, Geriatric Cardiology and Medicine Unit, University of Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Andrea Giosafat Marella Department of Clinical and Experimental Medicine, Geriatric Cardiology and Medicine Unit, University of Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Nadia Bartoli Department of Clinical and Experimental Medicine, Geriatric Cardiology and Medicine Unit, University of Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Mauro Di Bari Department of Clinical and Experimental Medicine, Geriatric Cardiology and Medicine Unit, University of Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Stefano Fumagalli Department of Clinical and Experimental Medicine, Geriatric Cardiology and Medicine Unit, University of Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Niccolò Marchionni Department of Clinical and Experimental Medicine, Geriatric Cardiology and Medicine Unit, University of Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
  • Francesca Tarantini Department of Clinical and Experimental Medicine, Geriatric Cardiology and Medicine Unit, University of Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Abstract

Background. Epicardial adipose tissue (EAT) is a visceral fat that fulfills two important functions: lipid-storage and secretion of adipokines with pro-inflammatory and pro-atherogenic properties. It has been suggested that EAT may affect the pathogenesis of atherosclerosis and the clinical course of coronary artery disease (CAD). In patients with obesity, diabetes and metabolic syndrome, the epicardial adipose tissue is enlarged. Little is known about the role of EAT in left ventricular dysfunction. Aim of this study was to evaluate the ability of insulin resistance to predict EAT thickness in patients with significant CAD and systolic dysfunction. Methods. We enrolled 114 subjects diagnosed with CAD by angiography. The majority underwent revascularization after an acute coronary syndrome. Patients were considered affected by significant left ventricular dysfunction when EF was

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Published
2013-12-30
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Original Articles
Keywords:
Epicardial fat, insulin resistance, coronary artery disease, adipokine, left ventricular dysfunction.
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How to Cite
Baldasseroni, S., Pratesi, A., Orso, F., Di Serio, C., Foschini, A., Marella, A. G., Bartoli, N., Di Bari, M., Fumagalli, S., Marchionni, N., & Tarantini, F. (2013). Epicardial adipose tissue and insulin resistance in patients with coronary artery disease with or without left ventricular dysfunction. Monaldi Archives for Chest Disease, 80(4). https://doi.org/10.4081/monaldi.2013.19