Obesity and ischemic heart disease. Is there a link between wellness’ diseases?

Submitted: December 9, 2015
Accepted: December 9, 2015
Published: December 9, 2015
Abstract Views: 1075
PDF: 829
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Obesity, the most common nutritional disorder in Western countries, is usually associated to cardiovascular diseases. However, the precise molecular pathways underlying this close association remain poorly understood. Nowadays, the adipose tissue is considered as an endocrine organ able to produce substances called adipo(cyto)kines that have different effects on lipid metabolism, closely involved in metabolic syndrome, and cardiovascular risk. The increased cardiovascular risk can be related also to peculiar dysfunction in the endocrine activity of adipose tissue observed in obesity responsible of vascular impairment (including endothelial dysfunction), prothrombotic tendency, and low-grade chronic inflammation. The present review aims at providing an up-dated overview on the adipocytederived molecules potentially involved in cardiovascular pathophysiology.

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Maresca, Fabio, Greta Luana D’Ascoli, Francesca Ziviello, Gianluca Petrillo, Vito Di Palma, Angelo Russo, Alessandra Grieco, and Plinio Cirillo. 2015. “Obesity and Ischemic Heart Disease. Is There a Link Between wellness’ Diseases?”. Monaldi Archives for Chest Disease 76 (1). https://doi.org/10.4081/monaldi.2011.201.

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