Obesity and ischemic heart disease. Is there a link between wellness’ diseases?

https://doi.org/10.4081/monaldi.2011.201

Authors

  • Fabio Maresca | pcirillo@unina.it Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli Federico II, Italy.
  • Greta Luana D’Ascoli Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli Federico II, Italy.
  • Francesca Ziviello Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli Federico II, Italy.
  • Gianluca Petrillo Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli Federico II, Italy.
  • Vito Di Palma Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli Federico II, Italy.
  • Angelo Russo Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli Federico II, Italy.
  • Alessandra Grieco Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli Federico II, Italy.
  • Plinio Cirillo Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli Federico II, Italy.

Abstract

Obesity, the most common nutritional disorder in Western countries, is usually associated to cardiovascular diseases. However, the precise molecular pathways underlying this close association remain poorly understood. Nowadays, the adipose tissue is considered as an endocrine organ able to produce substances called adipo(cyto)kines that have different effects on lipid metabolism, closely involved in metabolic syndrome, and cardiovascular risk. The increased cardiovascular risk can be related also to peculiar dysfunction in the endocrine activity of adipose tissue observed in obesity responsible of vascular impairment (including endothelial dysfunction), prothrombotic tendency, and low-grade chronic inflammation. The present review aims at providing an up-dated overview on the adipocytederived molecules potentially involved in cardiovascular pathophysiology.

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Published
2015-12-09
Info
Issue
Section
Reviews
Keywords:
adipokines, atherosclerosis, cardiovascular disease, endothelial function, inflammation, obesity
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How to Cite
Maresca, Fabio, Greta Luana D’Ascoli, Francesca Ziviello, Gianluca Petrillo, Vito Di Palma, Angelo Russo, Alessandra Grieco, and Plinio Cirillo. 2015. “Obesity and Ischemic Heart Disease. Is There a Link Between wellness’ Diseases?”. Monaldi Archives for Chest Disease 76 (1). https://doi.org/10.4081/monaldi.2011.201.

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