Failure of noninvasive prediction of pulmonary hypertension in patients with idiopathic pulmonary fibrosis

https://doi.org/10.4081/monaldi.2011.218

Authors

  • F. Salajka | salajka@fnhk.cz Department of Pneumology, University Hospital and Charles University Faculty of Medicine, Hradec Kralove, Czechia.
  • V. BartoÅ¡ Department of Pneumology, University Hospital and Charles University Faculty of Medicine, Hradec Kralove, Czechia.
  • J. Novosad Department of Clinical Immunology and Allergology, University Hospital and Charles University Faculty of Medicine, Hradec Kralove, Czechia.
  • J. Å t'ásek First Department of Internal Medicine, University Hospital and Charles University Faculty of Medicine, Hradec Kralove, Czechia.
  • J. Bis First Department of Internal Medicine, University Hospital and Charles University Faculty of Medicine, Hradec Kralove, Czechia.
  • M. Brtko Department of Cardiosurgery, University Hospital and Charles University Faculty of Medicine, Hradec Kralove, Czechia.
  • P. Polanský Department of Pneumology, University Hospital and Charles University Faculty of Medicine, Hradec Kralove, Czechia.
  • V. Koblížek Department of Pneumology, University Hospital and Charles University Faculty of Medicine, Hradec Kralove, Czechia.
  • V. Sedlák Department of Pneumology, University Hospital and Charles University Faculty of Medicine, Hradec Kralove, Czechia.

Abstract

Background. Pulmonary hypertension (PH) in patients with advanced idiopathic pulmonary fibrosis (IPF) is a complication connected with unfavorable prognosis. Great efforts have been made in attempting to establish a reliable non-invasive method which would enable detection of this complication. In this context a formula using pulmonary function parameters was published with outstanding results. Methods. We tested the formula in 27 IPF patients who underwent a lung function examination, cardiac ultrasonography and catheterisation on the same day. Results. Pulmonary hypertension was detected by catheterisation in 17 patients (63%). In our group, contrary to the published data, the aforementioned formula was neither useful for detecting patients with a high probability of PH nor as a means of calculating the mean pulmonary artery pressure in individual patients (p=0.502 and p=0.833, respectively). Ultrasound examination reached borderline correlation with the values measured by catheterisation when we compare patients with relevant results (r=0.531, p=0.051). However, the examination gave no usable results in 13 patients (48%). Conclusion. Our data suggests that no reliable, noninvasive method is currently available for detecting and confirming PH in IPF patients. We did not confirm the usefulness of the published formula. Further carefully organised studies will be necessary to verify or refute it.

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Published
2015-12-10
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How to Cite
Salajka, F., V. BartoÅ¡, J. Novosad, J. Å t’ásek, J. Bis, M. Brtko, P. Polanský, V. Koblížek, and V. Sedlák. 2015. “Failure of Noninvasive Prediction of Pulmonary Hypertension in Patients With Idiopathic Pulmonary Fibrosis”. Monaldi Archives for Chest Disease 75 (3). https://doi.org/10.4081/monaldi.2011.218.

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