https://doi.org/10.4081/monaldi.2023.2377
Hemophagocytic syndrome in a patient with long-term stable pulmonary sarcoidosis with progressive spleen and bone marrow lesion
Submitted: July 21, 2022
Accepted: December 27, 2022
Published: January 11, 2023
Accepted: December 27, 2022
Abstract Views: 994
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
An 83-year-old woman with asymptomatic pulmonary sarcoidosis presented to our hospital with fever and malaise for three months. Abdominal CT showed splenomegaly, and bone marrow examination revealed non-caseating granulomas. Pancytopenia was diagnosed due to bone marrow and splenic lesions of sarcoidosis. Steroid pulses were administered, but the patient died without response to treatment. Pathological autopsy results showed non-caseating granulomas and hemophagocytosis in the spleen and bone marrow. This suggested hemophagocytic syndrome, which was not suspected before death, in addition to sarcoidosis. In patients with splenomegaly and pancytopenia with history of pulmonary sarcoidosis, hemophagocytic syndrome should be considered in differential diagnosis.
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How to Cite
Fujimoto, Hazuki, Yohei Kanzawa, Hidemine Senba, Tetsuo Washio, Yukiko Kato, Kei Kawano, Shimpei Mizuki, et al. 2023. “Hemophagocytic Syndrome in a Patient With Long-Term Stable Pulmonary Sarcoidosis With Progressive Spleen and Bone Marrow Lesion”. Monaldi Archives for Chest Disease 93 (4). https://doi.org/10.4081/monaldi.2023.2377.
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