https://doi.org/10.4081/monaldi.2023.2499

Impact of immune status on the clinical characteristics, treatment outcomes and mortality of pulmonary nocardiosis: a retrospective analysis in a tertiary care hospital from a low- to middle-income country

Vol. 94 No. 2 (2024)
Submitted: November 30, 2022
Accepted: June 7, 2023
Published: June 26, 2023
Immune status, pulmonary nocardiosis, Pakistan
Abstract Views: 604
PDF: 6
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Authors

Syed Muhammad Zubair
https://orcid.org/0000-0002-5917-246X
Section of Pulmonary Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Muhammad Mustansir Mehdi Khan
https://orcid.org/0000-0003-2472-0486
Medical College, Aga Khan University, Karachi, Pakistan.
Yasmin Rahim
https://orcid.org/0000-0001-8746-3240
Kettering General Hospital, NHS Foundation Trust, United Kingdom.
Hamza Ahmed Ibad
https://orcid.org/0000-0003-1557-9484
Medical College, Aga Khan University, Karachi, Pakistan.
Muhammad Irfan
muhammad.irfan@aku.edu
https://orcid.org/0000-0002-5796-2548
Section of Pulmonary Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Nocardiosis is an opportunistic infection that primarily targets the immunosuppressed. We investigated the differences in demographics and characteristics between immunosuppressed and immunocompetent patients with nocardiosis in a tertiary care hospital in Pakistan. Retrospective records were reviewed for patients diagnosed with pulmonary nocardiosis between 2010 and 2020. Immunosuppressed individuals were identified as those with autoimmune diseases, hematologic diseases and malignancies, HIV, immunosuppressant therapy, etc. Data collected included basic demographics, comorbid conditions, medication history, clinical presentation, radiological and microbiological data, and nocardiosis outcomes and complications. A total of 66 patients with nocardiosis were included in this study, of whom 48 were immunosuppressed and 18 were immunocompetent. Both groups were compared for a number of variables, including patient characteristics, underlying conditions, radiological findings, treatment regimen, and outcomes. Immunosuppressed individuals were younger and had higher rates of diabetes, chronic renal disease, chronic liver disease, higher platelet counts, surgical intervention, and longer hospital stays. Fever, dyspnea, and sputum production were the most common presentations. Nocardia asteroides was found to be the most common species of Nocardia overall. Nocardiosis presents differently in immunosuppressed and immunocompetent patients, which is consistent with previous studies. Nocardiosis should be considered in any patient presenting with treatment-resistant pulmonary or neurological symptoms.

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Ethics Approval

The study protocol was approved by the Ethical Review Committee (ERC) of Aga Khan University (ERC No: 2019-0801-1195).

How to Cite

Zubair, Syed Muhammad, Muhammad Mustansir Mehdi Khan, Yasmin Rahim, Hamza Ahmed Ibad, and Muhammad Irfan. 2023. “Impact of Immune Status on the Clinical Characteristics, Treatment Outcomes and Mortality of Pulmonary Nocardiosis: A Retrospective Analysis in a Tertiary Care Hospital from a Low- to Middle-Income Country”. Monaldi Archives for Chest Disease 94 (2). https://doi.org/10.4081/monaldi.2023.2499.
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