Anabolic/Catabolic Imbalance in Chronic Heart Failure

https://doi.org/10.4081/monaldi.2010.266

Authors

  • Antonio Cittadini | antonio.cittadini@unina.it Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, Napoli, Italy.
  • Eduardo Bossone Cava de' Tirreni - Costa d'Amalfi, Salerno, Italy.
  • Alberto Maria Marra Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche,Università Federico II, Napoli, Italy.
  • Michele Arcopinto Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche,Università Federico II, Napoli, Italy.
  • Emanuele Bobbio Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche,Università Federico II, Napoli, Italy.
  • Salvatore Longobardi Merck Serono Group, Roma, Italy.
  • Carmine Cevara ASL NA 1 DS 29 UO Assistenza Anziani, Divisione di Cardiologia, Italy.
  • Sara Di Michele Dipartimento del Cuore e Grossi Vasi A. Reale, Università La Sapienza, Roma, Italy.
  • Luigi Saccà Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche,Università Federico II, Napoli, Italy.

Abstract

A metabolic imbalance between anabolic drive and catabolic forces is commonly observed in chronic heart failure (CHF) patients, with the latter prevailing over anabolic hormones. Moreover, anabolic deficiencies are independent markers of poor prognosis. This finding represents a solid background for the implementation of therapeutic trials based on replacement therapy. The somatotropic axis (GH/IGF-1) is the most powerful anabolic axis of the body and its decline is related with a poor outcome and a worse clinical status. Growth hormone (GH) administration may enter the therapeutic arena as adjunctive treatment in patients affected by CHF and GH/IGF-1 deficiency. The T.O.S.CA. project aims at investigating the relationship between CHF and hormonal deficiency.

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Published
2015-12-23
Info
Issue
Section
Editorial
Keywords:
Chronic Heart Failure, hormonal deficiency, Growth Hormone
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  • PDF: 349
How to Cite
Cittadini, Antonio, Eduardo Bossone, Alberto Maria Marra, Michele Arcopinto, Emanuele Bobbio, Salvatore Longobardi, Carmine Cevara, Sara Di Michele, and Luigi Saccà. 2015. “Anabolic/Catabolic Imbalance in Chronic Heart Failure”. Monaldi Archives for Chest Disease 74 (2). https://doi.org/10.4081/monaldi.2010.266.

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