Primary pleural haemangioendothelioma in an Italian female patient: a case report and review of the literature

https://doi.org/10.4081/monaldi.2010.298

Authors

  • M. Bocchino | marialuisa.bocchino@unina.it Department of Clinical and Experimental Medicine, “Federico II” University, Naples, Italy.
  • E. Barra Department of Pathology, Monaldi Hospital, Naples, Italy.
  • F. Lassandro Department of Radiology, Monaldi Hospital, Naples, Italy.
  • F. Ranieri Department of Radiology “Magrassi-Lanzara”, Second University of Naples, Naples, Italy.
  • R. Muto Department of Radiology, Monaldi Hospital, Naples, Italy.
  • G. Rea Department of Radiology, Monaldi Hospital, Naples, Italy.

Abstract

Primary epithelioid haemangioendothelioma (EHE) of the pleura is a rare vascular tumour that occurs mainly in men. Pleural effusion and thickening are the most common clinical presentations. A 58 year old female, nonsmoking patient presented to us with dry cough, dyspnoea and left chest pain for several weeks (no asbestos exposure). Standard chest X-ray and contrast enhanced multislice computed tomography revealed a large-size lobulated mass originating from the pleura which was diagnosed as primary pleural haemangioendothelioma (PHE) by histology and immunohistochemistry (reactivity for vimentin, CD31, CD34, Factor VIII and ulex europeaus). No metastases were detected. The patient refused treatment and died three months later due to the onset of acute and progressive respiratory failure. Despite the lack of highgrade malignancy, primary PHE displays a poor prognosis while curative therapies are actually not available. To our knowledge, this is the first case of primary PHE in a female patient occurring in Italy and the third one to have been reported in English literature. Difficulties in diagnosis and treatment management are discussed below.

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Published
2016-01-19
Info
Issue
Section
Case Reports
Keywords:
Haemangioendothelioma, Immunohistochemistry, Pleura
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How to Cite
Bocchino, M., E. Barra, F. Lassandro, F. Ranieri, R. Muto, and G. Rea. 2016. “Primary Pleural Haemangioendothelioma in an Italian Female Patient: A Case Report and Review of the Literature”. Monaldi Archives for Chest Disease 73 (3). https://doi.org/10.4081/monaldi.2010.298.

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