Influenza A H1N1 pneumonia in a patient with hairy-cell leukemia

https://doi.org/10.4081/monaldi.2010.305

Authors

  • A. Nicolini | antonello.nicolini@fastwebnet.it Division of Respiratory Diseases, General Hospital, Sestri Levante, Genova, Italy.
  • A. Perazzo Division of Respiratory Diseases, General Hospital, Sestri Levante, Genova, Italy.

Abstract

Severe pandemic influenza A virus (H1N1) infection is associated with risk factors such as pregnancy, obesity and immunosuppression. Immunocompromised patients are at increased risk of more severe or prolonged infection. We report a case of a hairy cell leukemia patient with H1N1 pneumonia which caused severe and prolonged illness. H1N1 virus pneumonia with meticillin-resistant Staphilococcus Aerues (MRSA) coinfection causing Acute Lung Injury (ALI) was treated with a double-dose of osentamyvir, a high dose of teicoplanin and a low dose of corticosteroids. Haematological findings included leucopenia, neutropenia, lymphopenia, reduction of γ-globulins and natural killer (NK) cells. Reduction of NK and γ-globulins may explain the development of severe illness and the prolonged illness Neutropenia may explain the MRSA co-infection. Lymphopenia is directly associated with virus action and is considered to be a marker of the swine influenza in adults.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Downloads

Published
2016-01-19
Info
Issue
Section
Case Reports
Keywords:
Influenza A H1N1 pneumonia, hairy cell leukemia, severe illness, prolonged course
Statistics
  • Abstract views: 437

  • PDF: 253
How to Cite
Nicolini, A., and A. Perazzo. 2016. “Influenza A H1N1 Pneumonia in a Patient With Hairy-Cell Leukemia”. Monaldi Archives for Chest Disease 73 (2). https://doi.org/10.4081/monaldi.2010.305.