Significant gas-exchange improvements reported after roflumilast in two cases of severe COPD
AbstractTwo cases of 63-year-old men with severe chronic obstructive pulmonary disease (COPD) associated with respiratory failure are presented. Both patients were treated with long acting bronchodilators, inhaled corticosteroids, theophylline, diuretics, long term oxygen therapy, and nocturnal non invasive mechanical ventilation, without achieving any improvement or control of the disease course. We observed a clinical and functional improvement in both patients when we added roflumilast to the pharmacological treatment schedule. In this context, gas exchange parameters were greatly improved, leading us to speculate on the possible mechanisms causing such improvements in these COPD patients.
- Abstract views: 400
- PDF: 426
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.