Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis

https://doi.org/10.4081/monaldi.2009.369

Authors

  • G.E. Carpagnano | ge.carpagnano@unifg.it Section of Respiratory Diseases, Department of Occupational and Medical Sciences, Faculty of Medicine, University of Foggia, Italy.
  • P. Carratù Institute of Respiratory Disease, University of Bari, Italy.
  • M. Gelardi Institute of Otorhinolaryngology, University of Bari, Italy.
  • A. Spanevello Fondazione Salvatore Maugeri, IRCCS, Cassano Murge, Italy.
  • G. Di Gioia Institute of Respiratory Disease, University of Bari, Italy.
  • T. Condreva Institute of Otorhinolaryngology, University of Bari, Italy.
  • O. Resta Institute of Respiratory Disease, University of Bari, Italy.
  • M.P. Foschino Barbaro Section of Respiratory Diseases, Department of Occupational and Medical Sciences, Faculty of Medicine, University of Foggia, Italy.

Abstract

Background and Aim. Nasal polyposis (NP) occurs in about 1-4% of the worldwide population. Increased plasma concentrations of different pro-inflammatory cytokines have been observed in NP, and might be related to the pathogenesis of this syndrome.The present study was designed to investigate IL-6 and IL-4 concentrations in nasal and oral exhaled breath condensate of patients with early and advanced NP, and following polypectomy. Methods. Ten individuals with polyposis in early status, twenty-three patients affected by advanced status of NP and ten healthy controls were enrolled into the study. Exhaled breath condensate was collected by all individuals, according to a previous standardised method. An immunoassay kit was used to measure IL-6 and IL-4 levels. Results. Concentrations of oral and nasal exhaled IL- 6 and IL-4 were significantly higher in patients with early nasal polyposis and advanced nasal polyposis, compared to healthy controls. A statistically significant decrease of nasally but not of orally exhaled IL-6 (p<0.001) and IL-4 (p<0.05) was observed after polypectomy. Conclusions. We consider oral and nasal exhaled condensate of IL-6 and IL-4 as valid inflammatory and oxidative stress marker in patients with nasal polyposis.

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Published
2016-01-25
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Original Articles
Keywords:
Exhaled breath condensate, Nasal polyposis, IL-6, IL-4, Polypectomy
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How to Cite
Carpagnano, G.E., P. Carratù, M. Gelardi, A. Spanevello, G. Di Gioia, T. Condreva, O. Resta, and M.P. Foschino Barbaro. 2016. “Increased IL-6 and IL-4 in Exhaled Breath Condensate of Patients With Nasal Polyposis”. Monaldi Archives for Chest Disease 71 (1). https://doi.org/10.4081/monaldi.2009.369.

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