https://doi.org/10.4081/monaldi.2009.369

Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis

Vol. 71 No. 1 (2009): Pulmonary series
Submitted: January 22, 2016
Accepted: January 22, 2016
Published: January 25, 2016
Exhaled breath condensate, Nasal polyposis, IL-6, IL-4, Polypectomy
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Authors

G.E. Carpagnano
ge.carpagnano@unifg.it
Section of Respiratory Diseases, Department of Occupational and Medical Sciences, Faculty of Medicine, University of Foggia, Italy.
P. Carratù
Institute of Respiratory Disease, University of Bari, Italy.
M. Gelardi
Institute of Otorhinolaryngology, University of Bari, Italy.
A. Spanevello
Fondazione Salvatore Maugeri, IRCCS, Cassano Murge, Italy.
G. Di Gioia
Institute of Respiratory Disease, University of Bari, Italy.
T. Condreva
Institute of Otorhinolaryngology, University of Bari, Italy.
O. Resta
Institute of Respiratory Disease, University of Bari, Italy.
M.P. Foschino Barbaro
Section of Respiratory Diseases, Department of Occupational and Medical Sciences, Faculty of Medicine, University of Foggia, Italy.
Background and Aim. Nasal polyposis (NP) occurs in about 1-4% of the worldwide population. Increased plasma concentrations of different pro-inflammatory cytokines have been observed in NP, and might be related to the pathogenesis of this syndrome.The present study was designed to investigate IL-6 and IL-4 concentrations in nasal and oral exhaled breath condensate of patients with early and advanced NP, and following polypectomy. Methods. Ten individuals with polyposis in early status, twenty-three patients affected by advanced status of NP and ten healthy controls were enrolled into the study. Exhaled breath condensate was collected by all individuals, according to a previous standardised method. An immunoassay kit was used to measure IL-6 and IL-4 levels. Results. Concentrations of oral and nasal exhaled IL- 6 and IL-4 were significantly higher in patients with early nasal polyposis and advanced nasal polyposis, compared to healthy controls. A statistically significant decrease of nasally but not of orally exhaled IL-6 (p<0.001) and IL-4 (p<0.05) was observed after polypectomy. Conclusions. We consider oral and nasal exhaled condensate of IL-6 and IL-4 as valid inflammatory and oxidative stress marker in patients with nasal polyposis.

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How to Cite

Carpagnano, G.E., P. Carratù, M. Gelardi, A. Spanevello, G. Di Gioia, T. Condreva, O. Resta, and M.P. Foschino Barbaro. 2016. “Increased IL-6 and IL-4 in Exhaled Breath Condensate of Patients With Nasal Polyposis”. Monaldi Archives for Chest Disease 71 (1). https://doi.org/10.4081/monaldi.2009.369.

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