Reticulocytes in untreated Obstructive Sleep Apnoea

https://doi.org/10.4081/monaldi.2008.387

Authors

  • O. Marrone | marrone@ibim.cnr.it National Research Council, Institute of Biomedicine and Molecular Immunology (IBIM), Palermo, Italy.
  • A. Salvaggio National Research Council, Institute of Biomedicine and Molecular Immunology (IBIM), Palermo, Italy.
  • M. Gioia V. Cervello Hospital, Laboratory of Clinical Pathology, Palermo, Italy.
  • A. Bonanno National Research Council, Institute of Biomedicine and Molecular Immunology (IBIM), Palermo, Italy.
  • M. Profita National Research Council, Institute of Biomedicine and Molecular Immunology (IBIM), Palermo, Italy.
  • L. Riccobono National Research Council, Institute of Biomedicine and Molecular Immunology (IBIM), Palermo, Italy.
  • A. Zito University of Palermo, Department of Medicine, Pneumology, Physiology, and Nutrition (DIMPEFINU), Palermo, Italy.
  • G. Insalaco National Research Council, Institute of Biomedicine and Molecular Immunology (IBIM), Palermo, Italy.
  • M.R. Bonsignore University of Palermo, Department of Medicine, Pneumology, Physiology, and Nutrition (DIMPEFINU), Palermo, Italy.

Abstract

Background and Aim. The short, repetitive hypoxaemic episodes observed in obstructive sleep apnoea (OSA) may determine small augmentations in mature red blood cells. It is unknown whether they affect reticulocyte release. This study explored whether the number and degree of maturation of circulating reticulocytes may be altered in OSA, possibly through the effect of erythropoietin. Methods. Fifty male adult patients with suspected OSA, normoxic during wakefulness, were studied. After nocturnal polysomnography, a blood sample was withdrawn for blood cells count, erythropoietin, iron and transferrin determination. Reticulocyte concentration and degree of immaturity [high (H), medium (M), or low (L)] were also determined. Immature reticulocyte fraction (IRF) was calculated as (M+H) percentage of reticulocytes. Results. A wide range of OSA severity was found [apnoea/ hypopnoea index (AHI): 44.3±30.4, range 0.3-105; sleep time spent at oxyhaemoglobin saturation 2% had higher EPO levels (p<0.05), but not worse nocturnal desaturations, than those with values <2%. By contrast, subjects with IRF <15% showed worse desaturations (p<0.05), but similar EPO concentrations, when compared to subjects whose IRF was <10%. At univariate analysis, reticulocyte count correlated to erythropoietin, while IRF to transferrin saturation, BMI and OSA severity. At multiple regression, only lowest nocturnal oxygen saturation remained a significant contributor to IRF (r2 0.223, p<0.05). Conclusions. This data suggests that hypoxaemia due to OSA could influence the release of immature reticulocytes, but this effect is not mediated by erythropoietin.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Downloads

Published
2016-01-26
Info
Issue
Section
Original Articles
Keywords:
Haematopoiesis, Nocturnal hypoxemia, Obstructive sleep apnoea, Erythropoietin
Statistics
  • Abstract views: 392

  • PDF: 290
How to Cite
Marrone, O., A. Salvaggio, M. Gioia, A. Bonanno, M. Profita, L. Riccobono, A. Zito, G. Insalaco, and M.R. Bonsignore. 2016. “Reticulocytes in Untreated Obstructive Sleep Apnoea”. Monaldi Archives for Chest Disease 69 (3). https://doi.org/10.4081/monaldi.2008.387.

Most read articles by the same author(s)