Italian survey on prevalence and disease management of chronic heart failure and chronic obstructive pulmonary disease comorbidity in ambulatory patients. SUSPIRIUM study rationale and design


  • Raffaele Griffo | Italian Association for Cardiovascular Prevention and Rehabilitation, Genova, Italy.
  • Antonio Spanevello Pulmonary Rehabilitation Unit, Salvatore Maugeri Foundation, IRCCS, Tradate and University of Insubria, Varese, Italy.
  • Pier Luigi Temporelli Division of Cardiology, Salvatore Maugeri Foundation, IRCCS, Veruno, Italy.
  • Pompilio Faggiano Division of Cardiology, Spedali Civili and University of Brescia, Italy.
  • Mauro Carone Division of Pneumology, Salvatore Maugeri Foundation, IRCCS, Cassano nelle Murge, Italy.
  • Giovanna Magni QBGROUP spa, Padova, Italy.
  • Nicolino Ambrosino Cardio-Pulmonary Rehab Department, Auxilium Vitae, Volterra, Italy.
  • Luigi Tavazzi Maria Cecilia Hospital, GVM Care&Research - E.S. Health Science Foundation, Cotignola, Italy.


Background. Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are leading causes of morbidity and mortality worldwide. Through shared risk factors and pathophysiological mechanisms, CHF and COPD frequently coexist. The concurrent disease has important therapeutic implications and independently predicts worsened mortality, impaired functional status, and health service use. However, assessment of the comorbidity varies widely according to the population studied, diagnostic criteria and measurement tools applied. Both syndromes have been studied extensively but largely separately, mostly in the domain of the pulmonologist for COPD and in the domain of the cardiologist for CHF. Study objectives and design. The aim of the study is to evaluate in an Italian outpatients setting (10 cardiology and 10 pulmonology centers from the same institution) the prevalence, clinical profile and the routine diagnostic, functional and therapeutic work-up applied by cardiologists and pulmonologists in the presence/suspicion of concurrent disease in patients in a stable phase of their disease. For this purpose, CHF and COPD outpatients will be enrolled in a multicenter, nationwide, prospective observational study. Risk estimation of comorbidity will be based on suspected, documented or patient-reported diagnosis of COPD/CHF. In the absence of documented concurrent diagnosis, each specialist will describe the diagnostic, functional and therapeutic work-up applied. Conclusion. The design of the study focused on the diagnostic validation of the CHF-COPD comorbidity aims to provide relevant new information on the assessment of the coexistent condition in the cardiac and pulmonary outpatients setting and on specialty-related different diagnostic and therapeutic strategies of comorbidity utilized in real life clinical practice. The symptomatic and prognostic benefits resulting from a combined approach to CHF/COPD could outweigh those attainable by treating either condition alone.



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Original Articles
chronic heart failure, chronic obstructive pulmonary disease, comorbidity, observational study
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How to Cite
Griffo, Raffaele, Antonio Spanevello, Pier Luigi Temporelli, Pompilio Faggiano, Mauro Carone, Giovanna Magni, Nicolino Ambrosino, and Luigi Tavazzi. 2015. “Italian Survey on Prevalence and Disease Management of Chronic Heart Failure and Chronic Obstructive Pulmonary Disease Comorbidity in Ambulatory Patients. SUSPIRIUM Study Rationale and Design”. Monaldi Archives for Chest Disease 82 (1).

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