Could IFN-γ predict the development of residual pleural thickening in tuberculous pleurisy?

https://doi.org/10.4081/monaldi.2008.407

Authors

  • I. Gerogianni | igerogianni@yahoo.gr Department of Respiratory Medicine, Medical School, University of Larissa, Larissa, Greece.
  • M. Papala Department of Respiratory Medicine, Medical School, University of Larissa, Larissa, Greece.
  • P. Tsopa Department of Respiratory Medicine, Medical School, University of Larissa, Larissa, Greece.
  • P. Zigoulis Department of Respiratory Medicine, Medical School, University of Larissa, Larissa, Greece.
  • A. Dimoulis Department of Respiratory Medicine, Medical School, University of Larissa, Larissa, Greece.
  • K. Kostikas Department of Respiratory Medicine, Medical School, University of Larissa, Larissa, Greece.
  • T. Kiropoulos Department of Respiratory Medicine, Medical School, University of Larissa, Larissa, Greece.
  • K.I. Gourgoulianis Department of Respiratory Medicine, Medical School, University of Larissa, Larissa, Greece.

Abstract

Background. The aim of our study was to identify predictive factors for the development of residual pleural thickening (RPT) in patients with tuberculous pleurisy (TP). Methods. A retrospective study of patients with pleural tuberculosis. The clinical and radiological characteristics, and measurements of microbiological and biochemical parameters or markers such as adenosine deaminase (ADA), interferon-γ (IFN-γ) and vascular endothelial growth factor (VEGF) in pleural fluid were studied. Results. Thirty one patients (24 male and 7 female) with a mean age of 55.9 years were studied. There were 25 (80.6%) patients with RPT > 2 mm and 6 (19.4%) patients without RPT. Ten patients (32.2%) had RPT ≥ 10 mm. The rate of pleural thickening was less in small effusions (p<0.05). IFN-γ was higher in patients with RPT ≥ 10 mm (p < 0.05) in comparison with those with RPT < 10 mm. Conclusions. Pleural fluid IFN-γ may deserve further investigation in order to build up preventive and therapeutic strategies against RPT and its clinical complications.

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Published
2016-01-26
Info
Issue
Section
TB Corner
Keywords:
Tuberculosis pleurisy, Pleural thickening, Adenosine deaminase, Interferon-γ
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How to Cite
Gerogianni, I., M. Papala, P. Tsopa, P. Zigoulis, A. Dimoulis, K. Kostikas, T. Kiropoulos, and K.I. Gourgoulianis. 2016. “Could IFN-γ Predict the Development of Residual Pleural Thickening in Tuberculous Pleurisy?”. Monaldi Archives for Chest Disease 69 (1). https://doi.org/10.4081/monaldi.2008.407.

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