Human genes in TB infection: their role in immune response

https://doi.org/10.4081/monaldi.2008.408

Authors

  • D. Lykouras University of Patras, University Hospital of Patras, Department of Internal Medicine, Division of Pneumology, Rio, Patras, Greece.
  • F. Sampsonas University of Patras, University Hospital of Patras, Department of Internal Medicine, Division of Pneumology, Rio, Patras, Greece.
  • A. Kaparianos University of Patras, University Hospital of Patras, Department of Internal Medicine, Division of Pneumology, Rio, Patras, Greece.
  • K. Karkoulias University of Patras, University Hospital of Patras, Department of Internal Medicine, Division of Pneumology, Rio, Patras, Greece.
  • G. Tsoukalas Chest Hospital Sotiria, Athens, Greece.
  • K. Spiropoulos | k-spiropoulos@hotmail.com University of Patras, University Hospital of Patras, Department of Internal Medicine, Division of Pneumology, Rio, Patras, Greece.

Abstract

Tuberculosis (TB) caused by the human pathogen Mycobacterium tuberculosis, is the leading cause of morbidity and mortality caused by infectious agents worldwide. Recently, there has been an ongoing concern about the clarification of the role of specific human genes and their polymorphisms involved in TB infection. In the vast majority of individuals, innate immune pathways and Thelper 1 (Th1) cell mediated immunity are activated resulting in the lysis of the bacterium. Firstly, PTPN22 R620W polymorphism is involved in the response to cases of infection. The Arg753Gln polymorphism in TLR-2 leads to a weaker response against the M. tuberculosis. The gene of the vitamin D receptor (VDR) has a few polymorphisms (BsmI, ApaI, Taq1, FokI) whose mixed genotypes alter the immune response. Solute carrier family 11 member (SLC11A1) is a proton/divalent cation antiporter that is more familiar by its former name NRAMP1 (natural resistance associated macrophage protein 1) and can affect M. tuberculosis growth. Polymorphisms of cytokines such as IL-10, IL-6, IFN-g, TNF-a, TGF-b1 can affect the immune response in various ways. Finally, a major role is played by M. tuberculosis antigens and the Ras-associated small GTP-ase 33A. As far as we know this is the first review that collates all these polymorphisms in order to give a comprehensive image of the field, which is currently evolving.

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Published
2016-01-26
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Issue
Section
TB Corner
Keywords:
TB, Genes, Polymorphism, Vitamin D, Cytokines
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How to Cite
Lykouras, D., F. Sampsonas, A. Kaparianos, K. Karkoulias, G. Tsoukalas, and K. Spiropoulos. 2016. “Human Genes in TB Infection: Their Role in Immune Response”. Monaldi Archives for Chest Disease 69 (1). https://doi.org/10.4081/monaldi.2008.408.

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