Exercise training reduces high mobility group box-1 protein levels in women with breast cancer: findings from the DIANA-5 study

https://doi.org/10.4081/monaldi.2014.45

Authors

  • Francesco Giallauria | giallauriafrancesco@gmail.com Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, Naples, Italy.
  • Marco Gentile Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
  • Paolo Chiodini Medical Statistics Unit, Second University of Naples, Naples, Italy.
  • Franco Berrino Department of Preventive and Predictive Medicine, National Cancer Institute, Milan, Italy.
  • Amalia Mattiello Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
  • Luigi Maresca Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, Naples, Italy.
  • Alessandra Vitelli Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, Naples, Italy.
  • Maria Mancini Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, Naples, Italy.
  • Alessandra Grieco Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, Naples, Italy.
  • Angelo Russo Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, Naples, Italy.
  • Rosa Lucci Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, Naples, Italy.
  • Giorgio Torella Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, Naples, Italy.
  • Salvatore Panico Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
  • Carlo Vigorito Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, Naples, Italy.

Abstract

Purpose: To determine whether exercise training might exert anti-inflammatory effect by reducing HMGB1 levels in women with breast cancer (BC). Methods: We analyzed monocentric data from the DIANA (DIET AND ANDROGENS)-5 PROJECT. Study population consisted of 94 patients randomized into two groups: 61 patients (53±8 yrs, training group) were assigned to a structured exercise training intervention (3 times/week for the first 3 months, and once /week for the following 9 months); whereas 33 patients (52±7 yrs, control group) followed only the general indications to adhere to the life-style intervention suggestions of the DIANA protocol. At study entry and after 12 months, all patients underwent cardiopulmonary exercise testing, biochemical assessment [HMGB1, high-sensitivity C-reactive protein (hs- CRP), interleukin-6 (IL-6)]; and lipid and glycemic profile. Results: There were no significant differences between groups in baseline clinical and inflammatory profile. Among the training group, only 19/61 patients had high adherence to the exercise intervention. After stratifying the study population according to the level of adhesion to the exercise intervention, 1-year HMGB1 levels were lower among patients more adherent to exercise (p for trend=0.001). Further adjusting for age, body mass index and baseline values, 1-year HMGB1 levels remained significantly and inversely associated to the level of adhesion to the exercise intervention (B=-0.97, SE=0.43, p=0.01). Conclusions: Moderate intensity exercise training in BC survivors is associated with reduced HMGB1 levels that are proportional to the level of adhesion to the exercise intervention, independently from other classical inflammatory molecules, suggesting an exercise-induced anti-inflammatory effect mediated by HMGB1.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Downloads

Published
2015-08-20
Info
Issue
Section
Original Articles
Keywords:
cancer, breast cancer, high mobility group box 1 protein, exercise training, cardiopulmonary exercise testing
Statistics
  • Abstract views: 1013

  • PDF: 725
How to Cite
Giallauria, Francesco, Marco Gentile, Paolo Chiodini, Franco Berrino, Amalia Mattiello, Luigi Maresca, Alessandra Vitelli, Maria Mancini, Alessandra Grieco, Angelo Russo, Rosa Lucci, Giorgio Torella, Salvatore Panico, and Carlo Vigorito. 2015. “Exercise Training Reduces High Mobility Group Box-1 Protein Levels in Women With Breast Cancer: Findings from the DIANA-5 Study”. Monaldi Archives for Chest Disease 82 (2). https://doi.org/10.4081/monaldi.2014.45.

Most read articles by the same author(s)

1 2 3 4 > >>