The role of Neopterin in cardiovascular disease

https://doi.org/10.4081/monaldi.2007.454

Authors

  • Mario Pacileo Division of Cardiology, University of Naples “Federico II”, Naples, Italy.
  • Plinio Cirillo | pcirillo@unina.it Division of Cardiology, University of Naples “Federico II”, Naples, Italy.
  • Salvatore De Rosa Division of Cardiology, University of Naples “Federico II”, Naples, Italy.
  • Grazia Ucci Division of Cardiology, University of Naples “Federico II”, Naples, Italy.
  • Gianluca Petrillo Division of Cardiology, University of Naples “Federico II”, Naples, Italy.
  • Sergio Musto D’Amore Division of Cardiology, University of Naples “Federico II”, Naples, Italy.
  • Laura Sasso Division of Cardiology, University of Naples “Federico II”, Naples, Italy.
  • Paola Maietta Division of Cardiology, University of Naples “Federico II”, Naples, Italy.
  • Raffaele Spagnuolo Division of Cardiology, University of Naples “Federico II”, Naples, Italy.
  • Massimo Chiariello Division of Cardiology, University of Naples “Federico II”, Naples, Italy.

Abstract

Inflammation plays a key role in the initiation and progression of atherosclerosis but also in the pathophysiology of atheromatous plaque disruption and the development of acute coronary syndromes. Neopterin is a marker of inflammation and of immune system activation, it is synthesized by macrophages, that, once activated, release this substance. Indeed, in clinical evaluation of patients, measurements of plasma levels of neopterin are usually used to evaluate progression of viral infections, renal transplant rejection, severe systemic inflammatory diseases, nephritic syndrome and several autoimmune diseases. This mediator is able to induce a pro-atherothrombotic phenotype in cells of the coronary circulation. Recent data indicate that serum levels of neopterin are elevated in patients with coronary and peripheral artery disease and seem to be a prognostic marker for major adverse cardiovascular events. In particular, neopterin levels predict future major cardiac and vascular adverse events in patients presenting with chronic coronary artery disease, with acute coronary syndromes, and in those with critical limb ischemia. This renders this molecule a useful marker of atherosclerotic plaque activity, permitting the identification of the subjects at highest risk for major adverse cardiovascular events. In line with the above mentioned evidences, patients with high neopterin levels may require aggressive risk factor modification and intensive medical treatment irrespective of the severity of their coronary artery disease. This data suggest a potential clinical use of neopterin as a marker for disease activity in patients with cardiovascular disease.

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Published
2016-02-01
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Issue
Section
Reviews
Keywords:
inflammation, neopterin, cardiovascular disease
Statistics
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  • PDF: 347
How to Cite
Pacileo, Mario, Plinio Cirillo, Salvatore De Rosa, Grazia Ucci, Gianluca Petrillo, Sergio Musto D’Amore, Laura Sasso, Paola Maietta, Raffaele Spagnuolo, and Massimo Chiariello. 2016. “The Role of Neopterin in Cardiovascular Disease”. Monaldi Archives for Chest Disease 68 (2). https://doi.org/10.4081/monaldi.2007.454.

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