Assessment and monitoring of ventilatory function and cough efficacy in patients with amyotrophic lateral sclerosis

https://doi.org/10.4081/monaldi.2007.509

Authors

  • A. Chetta | chetta@unipr.it Department of Clinical Sciences, Section of Respiratory Diseases; University of Parma, Italy.
  • M. Aiello Department of Clinical Sciences, Section of Respiratory Diseases; University of Parma, Italy.
  • P. Tzani Department of Clinical Sciences, Section of Respiratory Diseases; University of Parma, Italy.
  • D. Olivieri Department of Clinical Sciences, Section of Respiratory Diseases; University of Parma, Italy.

Abstract

Assessing and monitoring respiratory muscle function is crucial in patients with Amyotrophic Lateral Sclerosis, since impaired function can lead to either ventilatory failure or respiratory tract infection. Spirometry, diffusing capacity of the lung, breathing pattern, sleep study, blood gas analysis and respiratory muscle strength tests, as well as cough peak flow and cough expiratory volume measurements can provide relevant information on ventilatory function and cough efficacy. With regard to respiratory muscle strength testing, the rational approach consists in starting with volitional and non-invasive tests and later using invasive and non-volitional tests. This review focuses on both ventilatory and respiratory muscle strength testing, in order to undertake a timely treatment of respiratory failure and/or impaired cough efficacy. So far, the current literature has not highlighted any gold standard which stipulates when to commence ventilation and cough support in patients with Amyotrophic Lateral Sclerosis. A composite set of clinical and functional parameters is required for treatment scheduling to monitor lung involvement and follow-up in these patients.

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Published
2016-02-03
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Section
Reviews
Keywords:
Amyotrophic lateral sclerosis, respiratory muscle tests, cough, ventilatory failure, non-invasive positive pressure ventilation
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  • PDF: 421
How to Cite
Chetta, A., M. Aiello, P. Tzani, and D. Olivieri. 2016. “Assessment and Monitoring of Ventilatory Function and Cough Efficacy in Patients With Amyotrophic Lateral Sclerosis”. Monaldi Archives for Chest Disease 67 (1). https://doi.org/10.4081/monaldi.2007.509.

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