Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure: Part I

https://doi.org/10.4081/monaldi.2014.63

Authors

  • Domenico Sirico Department of Traslational Medical Sciences, University Federico II, Naples, Italy.
  • Andrea Salzano | andre.salzano@gmail.com Department of Traslational Medical Sciences, University Federico II, Naples, Italy.
  • Dario Celentani Città della Salute e della Scienza di Torino Hospital, Turin, Italy.
  • Michele Arcopinto Department of Cardiac Surgery, IRCCS Policlinico San Donato, Milan, Italy.
  • Alberto Maria Marra Department of Traslational Medical Sciences, University Federico II, Naples, Italy.
  • Emanuele Bobbio Department of Traslational Medical Sciences, University Federico II, Naples, Italy.
  • Angelo Russo Department of Traslational Medical Sciences, University Federico II, Naples, Italy.
  • Francesco Giallauria Department of Traslational Medical Sciences, University Federico II, Naples, Italy.
  • Carlo Vigorito Department of Traslational Medical Sciences, University Federico II, Naples, Italy.

Abstract

In recent years, the remarkable progress achieved in terms of survival after myocardial infarction have led to an increased incidence of chronic heart failure in survivors. This phenomenon is due to the still incomplete knowledge we possess about the complex pathophysiological mechanisms that regulate the response of cardiac tissue to ischemic injury. These involve various cell types such as fibroblasts, cells of the immune system, endothelial cells, cardiomyocytes and stem cells, as well as a myriad of mediators belonging to the system of cytokines and not only. In parallel with the latest findings on post-infarct remodeling, new potential therapeutic targets are arising to halt the progression of disease. In this review, we evaluate the results obtained from four new therapeutic strategies: in this part we evaluate gene therapy and novel aspect of stem cells therapy in remodeling; in the second part we will investigate, micro-RNA, posttranslational modification and microspheres based therapy.

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Published
2015-11-24
Info
Issue
Section
Reviews
Keywords:
cardiac remodeling, gene therapy, stem cells, micro-RNA, post-translational modification, microspheres, heart failure.
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How to Cite
Sirico, Domenico, Andrea Salzano, Dario Celentani, Michele Arcopinto, Alberto Maria Marra, Emanuele Bobbio, Angelo Russo, Francesco Giallauria, and Carlo Vigorito. 2015. “Anti Remodeling Therapy: New Strategies and Future Perspective in Post-Ischemic Heart Failure: Part I”. Monaldi Archives for Chest Disease 82 (4). https://doi.org/10.4081/monaldi.2014.63.

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