Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure. Part II

https://doi.org/10.4081/monaldi.2014.64

Authors

  • Andrea Salzano | andre.salzano@gmail.com Department of Traslational Medical Sciences, University Federico II, Naples, Italy.
  • Domenico Sirico Department of Traslational Medical Sciences, University Federico II, Naples, Italy.
  • Michele Arcopinto Department of Cardiac Surgery, IRCCS Policlinico San Donato, Milan, Italy.
  • Alberto Maria Marra Department of Traslational Medical Sciences, University Federico II, Naples, Italy.
  • Germano Guerra Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
  • Aldo Rocca Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy.
  • Alessandra Grieco Department of Traslational Medical Sciences, University Federico II, Naples, Italy.
  • Francesco Giallauria Department of Traslational Medical Sciences, University Federico II, Naples, Italy.
  • Carlo Vigorito Department of Traslational Medical Sciences, University Federico II, Naples, Italy.

Abstract

In recent years, the remarkable progress achieved in terms of survival after myocardial infarction have led to an increased incidence of chronic heart failure in survivors. This phenomenon is due to the still incomplete knowledge we possess about the complex pathophysiological mechanisms that regulate the response of cardiac tissue to ischemic injury. These involve various cell types such as fibroblasts, cells of the immune system, endothelial cells, cardiomyocytes and stem cells, as well as a myriad of mediators belonging to the system of cytokines and not only. In parallel with the latest findings on post-infarct remodeling, new potential therapeutic targets are arising to halt the progression of disease. After the evaluation of the results obtained from gene therapy and stem cells, in this part we evaluate micro- RNA, post-translational modification and microspheres based therapy.

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Published
2015-11-24
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Issue
Section
Reviews
Keywords:
cardiac remodeling, gene therapy, stem cells, micro-RNA, microspheres, heart failure.
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How to Cite
Salzano, Andrea, Domenico Sirico, Michele Arcopinto, Alberto Maria Marra, Germano Guerra, Aldo Rocca, Alessandra Grieco, Francesco Giallauria, and Carlo Vigorito. 2015. “Anti Remodeling Therapy: New Strategies and Future Perspective in Post-Ischemic Heart Failure. Part II”. Monaldi Archives for Chest Disease 82 (4). https://doi.org/10.4081/monaldi.2014.64.

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