New perspectives in cardiovascular risk reduction: focus on HDL

  • Stefania Paolillo Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
  • Giuseppe Luca Della Ratta Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
  • Alice Vitagliano Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
  • Annapaola Cirillo Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
  • Elisabetta Lardino Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
  • Tiziana Formisano Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
  • Irma Fabiani Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
  • Angela Maria Pellegrino Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
  • Pietro Riello Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
  • Pasquale Perrone Filardi | fpperron@unina.it Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.

Abstract

Cardiovascular diseases represent the leading cause of morbidity and mortality worldwide, mostly contributing to hospitalizations and health care costs. Dyslipidemias represent one of the major cardiovascular risk factor and its management, throughout life-style modifications and pharmacological interventions, has shown to reduce cardiac events. The risk of adverse cardiovascular events is related not only to elevated LDL blood levels, but also to decreased HDL concentrations, that exhibit protective effects in the development of atherosclerotic process. Aim of this review is to summarize current evidences about defensing effects of such lipoproteins and to show the most recent pharmacological strategies to reduce cardiovascular risk through the increase of their circulating levels.

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Published
2015-11-25
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Issue
Section
Reviews
Keywords:
dyslipidemia, HDL, cardiovascular risk
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How to Cite
Paolillo, S., Della Ratta, G. L., Vitagliano, A., Cirillo, A., Lardino, E., Formisano, T., Fabiani, I., Pellegrino, A. M., Riello, P., & Perrone Filardi, P. (2015). New perspectives in cardiovascular risk reduction: focus on HDL. Monaldi Archives for Chest Disease, 80(1). https://doi.org/10.4081/monaldi.2013.88