Cover Image

Echocardiographic evaluation of diastolic dysfunction in young and healthy patients with psoriasis: A case-control study

Elio Gorga, Marta Scodro, Francesca Valentini, Renzo D'Ortona, Mariachiara Arisi, Edoardo Sciatti, Ivano Bonadei, Valentina Regazzoni, Enrico Vizzardi, Marco Metra, Piergiacomo Calzavara Pinton
  • Marta Scodro
    University of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Italy
  • Francesca Valentini
    University of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Italy
  • Renzo D'Ortona
    University of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Italy
  • Mariachiara Arisi
    University of Brescia, Department of Dermatology, Spedali Civili of Brescia, Italy
  • Valentina Regazzoni
    University of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Italy

Abstract

Psoriasis is a systemic inflammatory disease with a great prevalence in general population. The inappropriate activation of the cellular immune system has been hypothesized to be an independent cardiovascular risk factor, given the higher incidence of cardiovascular disorders in psoriatic patients. Echocardiographic abnormalities have been demonstrated too: the aim of our study was to evaluate the presence of preclinical cardiac dysfunction in a cohort of psoriatic patients without cardiovascular risk factors. We enrolled 52 patients with the diagnosis of chronic plaque psoriasis, compared with a control group not affected by any relevant systemic diseases and inflammatory disorders. In all patients and control group, echocardiographic conventional and tissue Doppler (TDI) studies were conducted. The analysis of echocardiographic parameters revealed normal dimension, mass and systolic function of the left ventricle. Left ventricular diastolic dysfunction was found in 36.5% patients in the psoriasis group versus 0% in control group, and significant reduction of the E/A ratio was found also for the right ventricle. A significant increase of mitral regurgitation has been found in psoriatic patients (p=0.005). The early recognition of cardiovascular pre-clinic disease in psoriatic patients may guide a strict follow up and an early treatment, potentially improving cardiovascular prognosis.

Keywords

Psoriasis; diastolic disfunction; cardiovascular risk; atherosclerosis; echocardiography.

Full Text:

PDF
Submitted: 2018-03-26 21:57:47
Published: 2018-09-04 16:04:30
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
161

Views:
PDF
46

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2018 Elio Gorga, Marta Scodro, Francesca Valentini, Renzo D'Ortona, Mariachiara Arisi, Edoardo Sciatti, Ivano Bonadei, Valentina Regazzoni, Enrico Vizzardi, Marco Metra, Piergiacomo Calzavara Pinton

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185     •     Privacy