Prognostic impact of digoxin use for rate control of atrial fibrillation in patients ≥75 years of age

https://doi.org/10.4081/monaldi.2018.954

Authors

  • Maria Teresa La Rovere | mariateresa.larovere@icsmaugeri.it ICS Maugeri, IRCCS Montescano, Department of Cardiology, Italy.
  • Egidio Traversi ICS Maugeri, IRCCS Montescano, Department of Cardiology, Italy.

Abstract

Digoxin use remains a common therapeutic option in the pharmacological control of heart rate in patients with atrial fibrillation, endorsed in current guidelines with the same level of evidence than beta-blockers in patients with and without heart failure. Digoxin has a narrow therapeutic range and is influenced by drugâ€toâ€drug interactions, serum electrolyte concentrations, and renal function. Conflicting data exist regarding adverse outcomes that are associated with digoxin use in patients with atrial fibrillation. It remains unclear whether the association between digoxin use and worse clinical outcome is causal or may be the result of confounding by differences in the characteristics of patents including age, comorbidities and treatment. Particularly in older patients with atrial fibrillation, who are frequently prescribed a multitude of agents for stroke prevention, treatment of cardiovascular disease and other comorbidities, use of digoxin should be cautious and instituted with assessment of drug concentrations.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Downloads

Published
2018-06-07
Info
Issue
Section
Cardiology - Original Articles
Keywords:
Digoxin, atrial fibrillation, rate control, prognosis, age.
Statistics
  • Abstract views: 2616

  • PDF: 306
How to Cite
La Rovere, Maria Teresa, and Egidio Traversi. 2018. “Prognostic Impact of Digoxin Use for Rate Control of Atrial Fibrillation in Patients ≥75 Years of Age”. Monaldi Archives for Chest Disease 88 (2). https://doi.org/10.4081/monaldi.2018.954.

Most read articles by the same author(s)