Effect of uric acid serum levels on carotid arterial stiffness and intima-media thickness: A high resolution Echo-Tracking Study

https://doi.org/10.4081/monaldi.2019.1007

Authors

  • Francesco Antonini-Canterin Highly Specialized Rehabilitation Hospital in Motta Di Livenza, Cardiac Prevention and Rehabilitation Unit, Italy.
  • Concetta Di Nora | concetta.dinora@gmail.com University Hospital Santa Maria della Misericordia in Udine, Cardiothoracic Department, Italy.
  • Marco Pellegrinet Provincial Health Authority of Trento, Internal Medicine Unit, Italy.
  • Olga Vriz San Antonio Hospital in San Daniele del Friuli, Cardiology Department, Italy.
  • Salvatore La Carrubba Villa Sofia Hospital, Department of Internal Medicine, Italy.
  • Scipione Carerj University of Messina, Cardiology Department, Italy.
  • Concetta Zito University of Messina, Cardiology Department, Italy.
  • Anca Matescu Institute of Cardiovascular Diseases ‘Prof. Dr. C.C. Iliescu’, Romania.
  • Andreea Ravasel Institute of Cardiovascular Diseases ‘Prof. Dr. C.C. Iliescu’, Romania.
  • Iulian Cosei Institute of Cardiovascular Diseases ‘Prof. Dr. C.C. Iliescu’, Romania.
  • Bogdan A. Popescu Institute of Cardiovascular Diseases ‘Prof. Dr. C.C. Iliescu’, Romania.

Abstract

Serum uric acid (UA) has been shown to be a predictor of cardiovascular (CV) morbidity and mortality, and it may play a role in the pathogenesis of CV disease affecting vascular structure and function. However, there is limited evidence of its specific association with carotid artery stiffness and structure. The aim of our study was to evaluate whether UA is associated with early signs of atherosclerosis, namely local carotid arterial stiffness and intima-media thickening. We evaluated 698 consecutive asymptomatic patients, referred to the Cardiovascular Department for risk factors evaluation and treatment. All patients underwent carotid artery ultrasonography with measurement of common carotid intima-media thickness (IMT) and echo-tracking carotid artery stiffness index Beta. Patients with hyperuricemia (defined as serum uric acid ≥7 mg/dL in men and ≥6 mg/dL in women) had higher IMT (0.97±0.22 vs 0.91±0.18, p<0.001) and stiffness index Beta (8.3±3.2 vs 7.5±2.7, p=0.005). UA levels correlated with both IMT (r=0.225; p<0.001) and stiffness index Beta (r=0.154; p<0.001); the correlations were statistically significant in males and females. In a multivariate model which included age, arterial pressure, serum glucose and LDL-cholesterol, serum UA emerged as an independent explanatory variable of IMT and stiffness index Beta. Carotid IMT and local arterial stiffness are related to UA independently of established CV risk factors; UA may play a role in the early development of atherosclerosis.

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Published
2019-03-27
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Issue
Section
Cardiology - Original Articles
Keywords:
uric acid, arterial stiffness, vascular echography
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How to Cite
Antonini-Canterin, Francesco, Concetta Di Nora, Marco Pellegrinet, Olga Vriz, Salvatore La Carrubba, Scipione Carerj, Concetta Zito, Anca Matescu, Andreea Ravasel, Iulian Cosei, and Bogdan A. Popescu. 2019. “Effect of Uric Acid Serum Levels on Carotid Arterial Stiffness and Intima-Media Thickness: A High Resolution Echo-Tracking Study”. Monaldi Archives for Chest Disease 89 (1). https://doi.org/10.4081/monaldi.2019.1007.

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