@article{Nicolini_Perazzo_2016, title={Influenza A H1N1 pneumonia in a patient with hairy-cell leukemia}, volume={73}, url={https://www.monaldi-archives.org/macd/article/view/305}, DOI={10.4081/monaldi.2010.305}, abstractNote={Severe pandemic influenza A virus (H1N1) infection is associated with risk factors such as pregnancy, obesity and immunosuppression. Immunocompromised patients are at increased risk of more severe or prolonged infection. We report a case of a hairy cell leukemia patient with H1N1 pneumonia which caused severe and prolonged illness. H1N1 virus pneumonia with meticillin-resistant Staphilococcus Aerues (MRSA) coinfection causing Acute Lung Injury (ALI) was treated with a double-dose of osentamyvir, a high dose of teicoplanin and a low dose of corticosteroids. Haematological findings included leucopenia, neutropenia, lymphopenia, reduction of γ-globulins and natural killer (NK) cells. Reduction of NK and γ-globulins may explain the development of severe illness and the prolonged illness Neutropenia may explain the MRSA co-infection. Lymphopenia is directly associated with virus action and is considered to be a marker of the swine influenza in adults.}, number={2}, journal={Monaldi Archives for Chest Disease}, author={Nicolini, A. and Perazzo, A.}, year={2016}, month={Jan.} }