TY - JOUR AU - Cazzola, Mario AU - Matera, Maria Gabriella AU - Rogliani, Paola AU - Calzetta, Luigino PY - 2021/02/12 Y2 - 2024/03/29 TI - Comparative studies of dual bronchodilation in COPD JF - Monaldi Archives for Chest Disease JA - Monaldi Arch Chest Dis VL - 91 IS - 1 SE - Pneumology - Editorial DO - 10.4081/monaldi.2021.1625 UR - https://www.monaldi-archives.org/macd/article/view/1625 SP - AB - <p>Dual bronchodilation therapy is becoming the cornerstone for the treatment of COPD because the clinical benefits of LABA/LAMA fixed-dose combinations (FDCs) are now extensively established. Therefore, it not surprising that a number of LAMA/LABA combinations in a single inhaler have now been approved for clinical use as treatments for patients with COPD. Regrettably, very few head-to-head studies between all of the available LABA/LAMA FDCs have been carried out. This makes choosing the most appropriate FDC difficult. Comparative effectiveness research that also uses conventional meta-analyses to compare different care strategies can help generate useful information. A bidimensional comparative analysis across LAMA/LABA FDCs has suggested constant superiority for tiotropium/olodaterol. However, considering that there is not an equivalent amount of evidence on efficacy outcomes for all LAMA/LABA FDCs, a proper comparison between the different LAMA/LABA FDCs cannot be made yet, and the information available is still rather inconsistent.</p> ER -