TY - JOUR AU - Gerogianni, I. AU - Papala, M. AU - Tsopa, P. AU - Zigoulis, P. AU - Dimoulis, A. AU - Kostikas, K. AU - Kiropoulos, T. AU - Gourgoulianis, K.I. PY - 2016/01/26 Y2 - 2024/03/29 TI - Could IFN-γ predict the development of residual pleural thickening in tuberculous pleurisy? JF - Monaldi Archives for Chest Disease JA - Monaldi Arch Chest Dis VL - 69 IS - 1 SE - TB Corner DO - 10.4081/monaldi.2008.407 UR - https://www.monaldi-archives.org/macd/article/view/407 SP - AB - Background. The aim of our study was to identify predictive factors for the development of residual pleural thickening (RPT) in patients with tuberculous pleurisy (TP). Methods. A retrospective study of patients with pleural tuberculosis. The clinical and radiological characteristics, and measurements of microbiological and biochemical parameters or markers such as adenosine deaminase (ADA), interferon-γ (IFN-γ) and vascular endothelial growth factor (VEGF) in pleural fluid were studied. Results. Thirty one patients (24 male and 7 female) with a mean age of 55.9 years were studied. There were 25 (80.6%) patients with RPT > 2 mm and 6 (19.4%) patients without RPT. Ten patients (32.2%) had RPT ≥ 10 mm. The rate of pleural thickening was less in small effusions (p<0.05). IFN-γ was higher in patients with RPT ≥ 10 mm (p < 0.05) in comparison with those with RPT < 10 mm. Conclusions. Pleural fluid IFN-γ may deserve further investigation in order to build up preventive and therapeutic strategies against RPT and its clinical complications. ER -