https://doi.org/10.4081/monaldi.2019.1052

Probe-based confocal laser endomicroscopy in diagnosis of desquamative interstitial pneumonia in nonsmoker

Vol. 89 No. 3 (2019)
Submitted: February 22, 2019
Accepted: July 5, 2019
Published: September 10, 2019
confocal laser endomicroscopy, optical biopsy, interstitial lung diseases, idiopathic interstitial pneumonias, desquamative interstitial pneumonia
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Authors

Igor S. Mamenko
dr.mamenko.is@gmail.com
St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia; Medical Faculty, St. Petersburg State University, St. Petersburg, Russian Federation.
Igor V. Vasilev
St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, St. Petersburg, Russian Federation.
Irina A. Tabanakova
St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, St. Petersburg, Russian Federation.
Sultan M. Gasanmagomedov
St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Russian Federation.
Vera V. Sysoeva
St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Russian Federation.
Alexey D. Ushkov
St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Russian Federation.
Tatiana A. Novickaya
St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia; Medical Faculty, St. Petersburg State University, St. Petersburg, Russian Federation.
Piotr K. Yablonskii
St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia; Medical Faculty, St. Petersburg State University, St. Petersburg, Russian Federation.

Desquamative interstitial pneumonia is a rare disease that is predominantly associated with smoking. Surgical biopsy is usually recommended for the diagnosis of this disorder. Probe-based confocal laser endomicroscopy (pCLE) is a new method of minimally invasive in vivo microscopic image of airways and alveoli. We use this method for desquamative interstitial pneumonia in nonsmoker. The pCLE image shows thickened intra-alveolar septae and clusters of autofluorescent cells within the alveoli, which is unusual for non-smoking patients. We think this pattern can be used for differential diagnosis of desquamative interstitial pneumonia in nonsmokers.

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How to Cite

Mamenko, Igor S., Igor V. Vasilev, Irina A. Tabanakova, Sultan M. Gasanmagomedov, Vera V. Sysoeva, Alexey D. Ushkov, Tatiana A. Novickaya, and Piotr K. Yablonskii. 2019. “Probe-Based Confocal Laser Endomicroscopy in Diagnosis of Desquamative Interstitial Pneumonia in Nonsmoker”. Monaldi Archives for Chest Disease 89 (3). https://doi.org/10.4081/monaldi.2019.1052.

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