https://doi.org/10.4081/monaldi.2020.1231
Proteomic characterization of idiopathic pulmonary fibrosis patients: stable versus acute exacerbation
Accepted: March 10, 2020
Supplementary: 230
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Acute exacerbations (AEs) are among the main causes of death in idiopathic pulmonary fibrosis (IPF) patients. In this study proteomic comparative analysis of bronchoalveolar lavage (BAL) fluid samples was performed in stable IPF patients versus AEs IPF group to identify AE pathogenetic mechanisms and novel potential predictive biomarkers. A functional proteomic analysis of BAL fluid samples from stable and AE-IPF patients was conducted in a population of 27 IPF patients. Fifty-one differentially abundant spots were observed and identified by mass spectrometry. Enrichment analysis found proteins of interest involved in the regulation of macrophages and lipid metabolism receptors. In acute exacerbation IPF group, differentially abundant proteins were involved in propagation of the β-catenin WNT transduction signal, and proteins up-regulated in lung carcinogenesis (IGKC, S100A9, PEDF, IGHG1, ALDOA, A1AT, HPT, CO3 and PIGR) and acute phase proteins involved in protease-antiprotease imbalance (such as A1AT fragments). Dot-blot analysis of A1AT C-36 peptide allowed validating our findings, confirming up-regulation in AE IPF patients and suggesting its potential pathogenetic role. A crucial role of protease/antiprotease imbalance, clathrin-mediated endocytosis signalling and carcinogenesis emerged in IPF patients developing acute exacerbations.
How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Cesare Greco, Rivaroxaban in non valvular atrial fibrillation: subgroups analysis , Monaldi Archives for Chest Disease: Vol. 82 No. 1 (2014): Cardiac series
- M. Di Paolo, B. Guidi, L. Bruschini, G. Vessio, R. Domenici, N. Ambrosino, Unexpected delayed death after manual strangulation: need for careful examination in the emergency room , Monaldi Archives for Chest Disease: Vol. 71 No. 3 (2009): Pulmonary series
- G. Caramori, G. Bettoncelli, M. Carone, R. Tosatto, P. Di Blasi, A. Pieretto, G. Invernizzi, B. Franco Novelletto, A. Ciaccia, I.M. Adcock, A. Papi, Degree of control of physiciandiagnosed asthma and COPD in Italy , Monaldi Archives for Chest Disease: Vol. 67 No. 1 (2007): Pulmonary series
- M. Messina, N. Scichilone, F. Guddo, V. Bellia, Rapidly progressive organising pneumonia associated with cytomegalovirus infection in a patient with psoriasis , Monaldi Archives for Chest Disease: Vol. 67 No. 3 (2007): Pulmonary series
- Biagio Polla, Roflumilast is effective in reducing COPD related exacerbations and improving CAT score , Monaldi Archives for Chest Disease: Vol. 79 No. 3-4 (2013): Pulmonary series - Supplement 1
- Silvia Faverzani, Filippo Nocera, Ernesto Crisafulli, Maurizio Marvisi, Andrea Becciolini, Federica Mosetti, Eleonora Di Donato, Flavio Mozzani, Daniele Santilli, Giuseppe Scopelliti, Alarico Ariani, Home-based unsupervised pulmonary rehabilitation program improves the respiratory disability in systemic sclerosis patients with dyspnea: an observational prospective study , Monaldi Archives for Chest Disease: Vol. 92 No. 3 (2022)
- Marta Lazzeri, Andrea Lanza, Raffaella Bellini, Angela Bellofiore, Simone Cecchetto, Alessia Colombo, Francesco D'Abrosca, Cesare Del Monaco, Giuseppe Gaudiello, Mara Paneroni, Emilia Privitera, Mariangela Retucci, Veronica Rossi, Martina Santambrogio, Maurizio Sommariva, Pamela Frigerio, Respiratory physiotherapy in patients with COVID-19 infection in acute setting: a Position Paper of the Italian Association of Respiratory Physiotherapists (ARIR) , Monaldi Archives for Chest Disease: Vol. 90 No. 1 (2020)
- Michele Correale, Agostino Lopizzo, Francesco Santoro, Antonio Ruggero, Andrea Cuculo, Riccardo Leva, Matteo Di Biase, Acute heart failure in an adult with unrecognized congenital heart disease , Monaldi Archives for Chest Disease: Vol. 76 No. 3 (2011): Cardiac series
- G. Domenighetti, A. Moccia, R. Gayer, Observational case-control study of non-invasive ventilation in patients with ARDS , Monaldi Archives for Chest Disease: Vol. 69 No. 1 (2008): Pulmonary series
- Michele Vitacca, Beatrice Salvi, Marta Lazzeri, Elisabetta Zampogna, Giancarlo Piaggi, Piero Ceriana, Serena Cirio, Luigino Rizzello, Grazia Lacala, Angelo Longoni, Vittoria Galimberti, Patrizia D'Ambrosio, Enrica Pavesi, Giuseppe La Piana, Antonella Sanniti, Alessandro Morandi, Manoel Vallet, Mara Paneroni, Respiratory rehabilitation for patients with COVID-19 infection and chronic respiratory failure: a real-life retrospective study by a Lombard network , Monaldi Archives for Chest Disease: Vol. 92 No. 3 (2022)
<< < 30 31 32 33 34 35 36 37 38 39 > >>
You may also start an advanced similarity search for this article.
