https://doi.org/10.4081/monaldi.2021.1697
IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population
Submitted: November 24, 2020
Accepted: December 20, 2021
Published: December 28, 2021
Accepted: December 20, 2021
Abstract Views: 2162
PDF: 441
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Asthma is a chronic and multifactorial disease which is known to result from environmental and genetic factors. Interleukin 1 receptor-like 1 (IL1RL1) is a receptor, which promotes inflammatory responses after binding to its ligand IL-33. Several studies have shown that IL1RL1 gene polymorphisms are related to susceptibility or protection to asthma. The objective of this study was to evaluate the association between two IL1RL1 single nucleotide polymorphisms (rs10208293 and rs1041973) and the risk of asthma in the Iranian population. We performed genotyping of the IL1RL1 SNPs in 126 adult asthmatics and 300 healthy controls using TaqMan genotyping assay. Moreover, total serum IgE level, eosinophil count, and skin prick test were accomplished. The results indicated that the AA genotype of rs10208293 was positively associated with asthma susceptibility (p=0.028). We did not find any association between rs1041973 and asthma. Overall, our findings indicate that rs10208293 has a positive association with asthma in the Iranian population.
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How to Cite
Ranjbar, Maral, Mojdeh Matloubi, Shaghayegh Sadegh, Morteza Fallahpour, Leila Janani, and Mohammad-Ali Assarehzadegan. 2021. “IL1RL1 Single Nucleotide Polymorphisms Are Associated With Asthma in the Iranian Population”. Monaldi Archives for Chest Disease 92 (3). https://doi.org/10.4081/monaldi.2021.1697.
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