https://doi.org/10.4081/monaldi.2021.1697
IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population
Submitted: November 24, 2020
Accepted: December 20, 2021
Published: December 28, 2021
Accepted: December 20, 2021
Abstract Views: 2142
PDF: 436
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Asthma is a chronic and multifactorial disease which is known to result from environmental and genetic factors. Interleukin 1 receptor-like 1 (IL1RL1) is a receptor, which promotes inflammatory responses after binding to its ligand IL-33. Several studies have shown that IL1RL1 gene polymorphisms are related to susceptibility or protection to asthma. The objective of this study was to evaluate the association between two IL1RL1 single nucleotide polymorphisms (rs10208293 and rs1041973) and the risk of asthma in the Iranian population. We performed genotyping of the IL1RL1 SNPs in 126 adult asthmatics and 300 healthy controls using TaqMan genotyping assay. Moreover, total serum IgE level, eosinophil count, and skin prick test were accomplished. The results indicated that the AA genotype of rs10208293 was positively associated with asthma susceptibility (p=0.028). We did not find any association between rs1041973 and asthma. Overall, our findings indicate that rs10208293 has a positive association with asthma in the Iranian population.
Mims JW. Asthma: definitions and pathophysiology. Int Forum Allergy Rhinol 2015;5:S2-6.
DOI: https://doi.org/10.1002/alr.21609
Masoli M, Fabian D, Holt S, et al. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469-78.
DOI: https://doi.org/10.1111/j.1398-9995.2004.00526.x
Fazlollahi MR, Najmi M, Fallahnezhad M, et al. The prevalence of asthma in Iranian adults: The first national survey and the most recent updates. Clin Respir J 2018;12:1872-81.
DOI: https://doi.org/10.1111/crj.12750
March ME, Sleiman PM, Hakonarson H. Genetic polymorphisms and associated susceptibility to asthma. Int J Gen Med 2013;6:253-65.
DOI: https://doi.org/10.2147/IJGM.S28156
Murphy GE, Xu D, Liew FY, et al. Role of interleukin 33 in human immunopathology. Ann Rheum Dis 2010;69:i43-47.
DOI: https://doi.org/10.1136/ard.2009.120113
Kumar S, Minnich MD, Young PR. ST2/T1 protein functionally binds to two secreted proteins from Balb/c 3T3 and human umbilical vein endothelial cells but does not bind interleukin 1. J Biol Chem 1995;270:27905-13.
DOI: https://doi.org/10.1074/jbc.270.46.27905
Griesenauer B, Paczesny S. The ST2/IL-33 axis in immune cells during inflammatory diseases. Front Immunol 2017;8:475.
DOI: https://doi.org/10.3389/fimmu.2017.00475
Iwahana H, Yanagisawa K, Ito-Kosaka A, et al. Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells. Eur J Biochem 1999;264:397-406.
DOI: https://doi.org/10.1046/j.1432-1327.1999.00615.x
Ciccone MM,Cortese F, Gesualdo M, et al. A novel cardiac bio-marker: ST2: a review. Molecules 2013;18:15314-28.
DOI: https://doi.org/10.3390/molecules181215314
Lingel A, Weiss TM, Niebuhr M, et al. Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes. Structure 2009;17:1398-410.
DOI: https://doi.org/10.1016/j.str.2009.08.009
Schmitz J, Owyang A, Oldham E, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005;23:479-90.
DOI: https://doi.org/10.1016/j.immuni.2005.09.015
Marth GT, Korf I, Yandell MD, et al. A general approach to single-nucleotide polymorphism discovery. Nat Genet 1999;23:452-6.
DOI: https://doi.org/10.1038/70570
Queiroz GA, Costa RS, Alcantara-Neves NM, et al. IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population. Int J Immunogenet 2017;44:51-61.
DOI: https://doi.org/10.1111/iji.12306
Akhabir L, Sandford A. Genetics of interleukin 1 receptor-like 1 in immune and inflammatory diseases. Curr Genomics 2010;11:591-606.
DOI: https://doi.org/10.2174/138920210793360907
Moffatt MF, Gut IG, Demenais F, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010;363:1211-21.
DOI: https://doi.org/10.1056/NEJMoa0906312
Torgerson DG, Ampleford EJ, Chiu GY, et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 2011;43:887-92.
DOI: https://doi.org/10.1038/ng.888
Grotenboer NS, Ketelaar ME, Koppelman GE, et al. Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology. J Allergy Clin Immunol 2013;131:856-65.
DOI: https://doi.org/10.1016/j.jaci.2012.11.028
Zhang G, Lu J, Yin X, et al. Association of IL-33, IL1RL1 gene polymorphisms with serum IL-33 levels and risk of asthma in adults and asthmatic bronchitis in children (Chinese). Biotechnol Biotechnol Equip 2018;32:1251-6.
DOI: https://doi.org/10.1080/13102818.2018.1471361
Savenije OE, Mahachie John JM, Granell R, et al. Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood. J Allergy Clin Immunol 2014;134:170-7.
DOI: https://doi.org/10.1016/j.jaci.2013.12.1080
Wu H, Romieu I, Shi M, et al. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. J Allergy Clin Immunol 2010;125:321-7.e13.
DOI: https://doi.org/10.1016/j.jaci.2009.09.007
Savenije OE, Kerkhof M, Reijmerink NE, et al. Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol 2011;127:750-6.e1-5.
DOI: https://doi.org/10.1016/j.jaci.2010.12.014
Reijmerink NE, Postma DS, Bruinenberg M, et al. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. J Allergy Clin Immunol 2008;122:651-4.e8.
DOI: https://doi.org/10.1016/j.jaci.2008.06.030
Chen J, Zhang J, Hu H, et al. Polymorphisms of RAD50, IL33 and IL1RL1 are associated with atopic asthma in Chinese population. Tissue Antigens 2015;86:443-7.
DOI: https://doi.org/10.1111/tan.12688
Weber WW. Populations and genetic polymorphisms. Mol Diagn 1999;4:299-307.
DOI: https://doi.org/10.1016/S1084-8592(99)80006-X
Ranjbar M, Matloubi M, Assarehzadegan MA, et al. Association between two single nucleotide polymorphisms of thymic stromal lymphopoietin (TSLP) gene and asthma in Iranian population. Iran J Allergy Asthma Immunol 2020;19:362-72.
DOI: https://doi.org/10.18502/ijaai.v19i4.4111
Matloubi M, Ranjbar M, Assarehzadegan MA, et al. The impact of interleukin (IL)-33 gene polymorphisms and environmental factors on risk of asthma in the Iranian population. Lung 2020;198:105-12.
DOI: https://doi.org/10.1007/s00408-019-00301-9
[No authors listed]. Standardization of spirometry, 1994 update. American Thoracic Society. Am J Respir Crit Care Med 1995;152:1107-36.
DOI: https://doi.org/10.1164/ajrccm.152.3.7663792
Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143-78.
DOI: https://doi.org/10.1183/09031936.00138707
Assarehzadegan MA, Amini SA. Sensitization to common aeroallergens among asthmatic patients in a tropical region affected by dust storm. J Med Sci 2013;13:592-7.
DOI: https://doi.org/10.3923/jms.2013.592.597
Heinzerling L, Mari A, Bergmann KC, et al. The skin prick test - European standards. Clin Transl Allergy 2013;3:3.
DOI: https://doi.org/10.1186/2045-7022-3-3
Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
DOI: https://doi.org/10.1093/nar/16.3.1215
How to Cite
Ranjbar, Maral, Mojdeh Matloubi, Shaghayegh Sadegh, Morteza Fallahpour, Leila Janani, and Mohammad-Ali Assarehzadegan. 2021. “IL1RL1 Single Nucleotide Polymorphisms Are Associated With Asthma in the Iranian Population”. Monaldi Archives for Chest Disease 92 (3). https://doi.org/10.4081/monaldi.2021.1697.
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